New horizons in hypoxia signaling pathways

Investigation into the regulation of the erythropoietin gene by oxygen led to the discovery of a process of direct oxygen sensing that transduces many cellular and systemic responses to hypoxia. The oxygen-sensitive signal is generated through the catalytic action of a series of 2-oxoglutarate-depen...

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Detalhes bibliográficos
Main Authors: Pugh, C, Ratcliffe, P
Formato: Journal article
Publicado em: Elsevier 2017