Allele-specific DNA identity patterns.
A method of genetic analysis is presented which involves digestion of DNA with a single restriction enzyme (PvuII) and hybridisation with a mixture of five probes. Four of the five probes chosen recognise hypervariable regions (HVRs) of the human genome and hence an allele-specific DNA identity patt...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Springer-Verlag
1987
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| _version_ | 1797070483442630656 |
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| author | Wainscoat, J Pilkington, S Peto, T Bell, J Higgs, D |
| author_facet | Wainscoat, J Pilkington, S Peto, T Bell, J Higgs, D |
| author_sort | Wainscoat, J |
| collection | OXFORD |
| description | A method of genetic analysis is presented which involves digestion of DNA with a single restriction enzyme (PvuII) and hybridisation with a mixture of five probes. Four of the five probes chosen recognise hypervariable regions (HVRs) of the human genome and hence an allele-specific DNA identity pattern results. An advantage of this approach to genetic characterisation is that the complex identity patterns may be broken down into simple allelic systems of known chromosomal localization by hybridisation with the individual probes. Also different probes may be included in a combined probe designed for particular types of investigation. |
| first_indexed | 2024-03-06T22:39:30Z |
| format | Journal article |
| id | oxford-uuid:5b0df5ae-1ad9-43eb-8233-8f4a863bf0ee |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:39:30Z |
| publishDate | 1987 |
| publisher | Springer-Verlag |
| record_format | dspace |
| spelling | oxford-uuid:5b0df5ae-1ad9-43eb-8233-8f4a863bf0ee2022-03-26T17:19:42ZAllele-specific DNA identity patterns.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5b0df5ae-1ad9-43eb-8233-8f4a863bf0eeEnglishSymplectic Elements at OxfordSpringer-Verlag1987Wainscoat, JPilkington, SPeto, TBell, JHiggs, DA method of genetic analysis is presented which involves digestion of DNA with a single restriction enzyme (PvuII) and hybridisation with a mixture of five probes. Four of the five probes chosen recognise hypervariable regions (HVRs) of the human genome and hence an allele-specific DNA identity pattern results. An advantage of this approach to genetic characterisation is that the complex identity patterns may be broken down into simple allelic systems of known chromosomal localization by hybridisation with the individual probes. Also different probes may be included in a combined probe designed for particular types of investigation. |
| spellingShingle | Wainscoat, J Pilkington, S Peto, T Bell, J Higgs, D Allele-specific DNA identity patterns. |
| title | Allele-specific DNA identity patterns. |
| title_full | Allele-specific DNA identity patterns. |
| title_fullStr | Allele-specific DNA identity patterns. |
| title_full_unstemmed | Allele-specific DNA identity patterns. |
| title_short | Allele-specific DNA identity patterns. |
| title_sort | allele specific dna identity patterns |
| work_keys_str_mv | AT wainscoatj allelespecificdnaidentitypatterns AT pilkingtons allelespecificdnaidentitypatterns AT petot allelespecificdnaidentitypatterns AT bellj allelespecificdnaidentitypatterns AT higgsd allelespecificdnaidentitypatterns |