ALDH2 mediates 5-nitrofuran activity in multiple species

ALDH2 mediates 5-nitrofuran activity in multiple species

Understanding how drugs work in vivo is critical for drug design and for maximizing the potential of currently available drugs. 5-nitrofurans are a class of prodrugs widely used to treat bacterial and trypanosome infections, but despite relative specificity, 5-nitrofurans often cause serious toxic s...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Zhou, L, Ishizaki, H, Spitzer, M, Taylor, KL, Temperley, ND, Johnson, SL, Brear, P, Gautier, P, Zeng, Z, Mitchell, A, Narayan, V, McNeil, EM, Melton, DW, Smith, TK, Tyers, M, Westwood, NJ, Patton, EE
Format: Journal article
Sprache:English
Veröffentlicht: Elsevier 2012

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