Interethnic analyses of blood pressure loci in populations of East Asian and European descent
Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We repor...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
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Nature Publishing Group
2018
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| _version_ | 1826274207809404928 |
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| author | Takeuchi, F Akiyama, M Matoba, N Bennett, D Lin, K Clarke, R Walters, R Millwood, I Chen, Z International Genomics of Blood Pressure (iGEN-BP) Consortium Mark I., M |
| author_facet | Takeuchi, F Akiyama, M Matoba, N Bennett, D Lin, K Clarke, R Walters, R Millwood, I Chen, Z International Genomics of Blood Pressure (iGEN-BP) Consortium Mark I., M |
| author_sort | Takeuchi, F |
| collection | OXFORD |
| description | Blood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP. |
| first_indexed | 2024-03-06T22:39:57Z |
| format | Journal article |
| id | oxford-uuid:5b356791-fc15-425d-99eb-2f2ad36d1c2c |
| institution | University of Oxford |
| last_indexed | 2024-03-06T22:39:57Z |
| publishDate | 2018 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:5b356791-fc15-425d-99eb-2f2ad36d1c2c2022-03-26T17:20:37ZInterethnic analyses of blood pressure loci in populations of East Asian and European descentJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5b356791-fc15-425d-99eb-2f2ad36d1c2cSymplectic Elements at OxfordNature Publishing Group2018Takeuchi, FAkiyama, MMatoba, NBennett, DLin, KClarke, RWalters, RMillwood, IChen, ZInternational Genomics of Blood Pressure (iGEN-BP) ConsortiumMark I., MBlood pressure (BP) is a major risk factor for cardiovascular disease and more than 200 genetic loci associated with BP are known. Here, we perform a multi-stage genome-wide association study for BP (max N = 289,038) principally in East Asians and meta-analysis in East Asians and Europeans. We report 19 new genetic loci and ancestry-specific BP variants, conforming to a common ancestry-specific variant association model. At 10 unique loci, distinct non-rare ancestry-specific variants colocalize within the same linkage disequilibrium block despite the significantly discordant effects for the proxy shared variants between the ethnic groups. The genome-wide transethnic correlation of causal-variant effect-sizes is 0.898 and 0.851 for systolic and diastolic BP, respectively. Some of the ancestry-specific association signals are also influenced by a selective sweep. Our results provide new evidence for the role of common ancestry-specific variants and natural selection in ethnic differences in complex traits such as BP. |
| spellingShingle | Takeuchi, F Akiyama, M Matoba, N Bennett, D Lin, K Clarke, R Walters, R Millwood, I Chen, Z International Genomics of Blood Pressure (iGEN-BP) Consortium Mark I., M Interethnic analyses of blood pressure loci in populations of East Asian and European descent |
| title | Interethnic analyses of blood pressure loci in populations of East Asian and European descent |
| title_full | Interethnic analyses of blood pressure loci in populations of East Asian and European descent |
| title_fullStr | Interethnic analyses of blood pressure loci in populations of East Asian and European descent |
| title_full_unstemmed | Interethnic analyses of blood pressure loci in populations of East Asian and European descent |
| title_short | Interethnic analyses of blood pressure loci in populations of East Asian and European descent |
| title_sort | interethnic analyses of blood pressure loci in populations of east asian and european descent |
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