Direct measurement of the male recombination fraction in the human beta-globin hot spot.
Recombination was measured across nine intervals in the human beta-globin gene cluster by single-sperm analysis. A recombination fraction of approximately 0.9% was calculated across an approximately 11 kb region using a new method to estimate recombination fractions from single-sperm typing data. No...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2002
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| _version_ | 1826274236446015488 |
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| author | Schneider, J Peto, T Boone, R Boyce, A Clegg, J |
| author_facet | Schneider, J Peto, T Boone, R Boyce, A Clegg, J |
| author_sort | Schneider, J |
| collection | OXFORD |
| description | Recombination was measured across nine intervals in the human beta-globin gene cluster by single-sperm analysis. A recombination fraction of approximately 0.9% was calculated across an approximately 11 kb region using a new method to estimate recombination fractions from single-sperm typing data. No recombination was detected in an adjacent approximately 90 kb region that extends upstream of the beta-globin cluster. These data are consistent with previous estimates based on population genetic analysis, and suggest a recombination rate of nearly two orders of magnitude greater than the genome average of approximately 1 cM/Mb. Because recombination hot spots will destroy linkage disequilibrium across small physical regions, knowledge about the location and strength of such hot spots could be extremely valuable for genetic association studies. |
| first_indexed | 2024-03-06T22:40:23Z |
| format | Journal article |
| id | oxford-uuid:5b582f4f-90e5-4faa-8010-a0492f8e291b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:40:23Z |
| publishDate | 2002 |
| record_format | dspace |
| spelling | oxford-uuid:5b582f4f-90e5-4faa-8010-a0492f8e291b2022-03-26T17:21:28ZDirect measurement of the male recombination fraction in the human beta-globin hot spot.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5b582f4f-90e5-4faa-8010-a0492f8e291bEnglishSymplectic Elements at Oxford2002Schneider, JPeto, TBoone, RBoyce, AClegg, JRecombination was measured across nine intervals in the human beta-globin gene cluster by single-sperm analysis. A recombination fraction of approximately 0.9% was calculated across an approximately 11 kb region using a new method to estimate recombination fractions from single-sperm typing data. No recombination was detected in an adjacent approximately 90 kb region that extends upstream of the beta-globin cluster. These data are consistent with previous estimates based on population genetic analysis, and suggest a recombination rate of nearly two orders of magnitude greater than the genome average of approximately 1 cM/Mb. Because recombination hot spots will destroy linkage disequilibrium across small physical regions, knowledge about the location and strength of such hot spots could be extremely valuable for genetic association studies. |
| spellingShingle | Schneider, J Peto, T Boone, R Boyce, A Clegg, J Direct measurement of the male recombination fraction in the human beta-globin hot spot. |
| title | Direct measurement of the male recombination fraction in the human beta-globin hot spot. |
| title_full | Direct measurement of the male recombination fraction in the human beta-globin hot spot. |
| title_fullStr | Direct measurement of the male recombination fraction in the human beta-globin hot spot. |
| title_full_unstemmed | Direct measurement of the male recombination fraction in the human beta-globin hot spot. |
| title_short | Direct measurement of the male recombination fraction in the human beta-globin hot spot. |
| title_sort | direct measurement of the male recombination fraction in the human beta globin hot spot |
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