The interaction of growth hormone releasing hormone with other hypothalamic hormones on the release of anterior pituitary hormones.
To determine whether the 29 amino-acid fragment of growth hormone releasing hormone (GHRH) can be combined with other hypothalamic releasing hormones in a single test of anterior pituitary reserve, the responses of anterior pituitary hormones to combinations of an i.v. bolus of GHRH(1-29)NH2 or sali...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
1986
|
| _version_ | 1826274239048581120 |
|---|---|
| author | Looij, B Nieuwenhuijzen Kruseman, A Mudde, A Frölich, M Piaditis, G Hodgkinson, S McLean, C Grossman, A Coy, D Rees, L |
| author_facet | Looij, B Nieuwenhuijzen Kruseman, A Mudde, A Frölich, M Piaditis, G Hodgkinson, S McLean, C Grossman, A Coy, D Rees, L |
| author_sort | Looij, B |
| collection | OXFORD |
| description | To determine whether the 29 amino-acid fragment of growth hormone releasing hormone (GHRH) can be combined with other hypothalamic releasing hormones in a single test of anterior pituitary reserve, the responses of anterior pituitary hormones to combinations of an i.v. bolus of GHRH(1-29)NH2 or saline with an i.v. bolus of either LH releasing hormone (LHRH) plus TRH, ovine CRH(oCRH) or saline were studied. Each infusion of GHRH(1-29)NH2 resulted in a rapid increment of the plasma GH value. Infusion of GHRH(1-29)NH2 also caused a small and transient rise in plasma PRL, but no change in the integrated PRL response. The combination of GHRH(1-29)NH2 with LHRH plus TRH caused a larger increment of peak and integrated plasma TSH levels than LHRH plus TRH alone. GHRH(1-29)NH2 did not affect the release of other anterior pituitary hormones after infusion with oCRH or LHRH plus TRH. Because of the finding of potentiation of the TSH-releasing activity of LHRH plus TRH by GHRH(1-29)NH2, the study was extended to the investigation of TSH release after infusion of TRH in combination with either GHRH(1-29)NH2 or GHRH(1-40). In this study the combination of TRH with both GHRH preparations also caused a larger increment of the peak and integrated plasma TSH levels than TRH alone. It is concluded that GHRH(1-29)NH2 possesses moderate PRL-releasing activity apart from GH-releasing activity. In addition, GHRH potentiates the TSH-releasing activity of TRH.(ABSTRACT TRUNCATED AT 250 WORDS) |
| first_indexed | 2024-03-06T22:40:26Z |
| format | Journal article |
| id | oxford-uuid:5b5b1150-e242-44ee-b6fe-a4ba40a947a6 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:40:26Z |
| publishDate | 1986 |
| record_format | dspace |
| spelling | oxford-uuid:5b5b1150-e242-44ee-b6fe-a4ba40a947a62022-03-26T17:21:34ZThe interaction of growth hormone releasing hormone with other hypothalamic hormones on the release of anterior pituitary hormones.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5b5b1150-e242-44ee-b6fe-a4ba40a947a6EnglishSymplectic Elements at Oxford1986Looij, BNieuwenhuijzen Kruseman, AMudde, AFrölich, MPiaditis, GHodgkinson, SMcLean, CGrossman, ACoy, DRees, LTo determine whether the 29 amino-acid fragment of growth hormone releasing hormone (GHRH) can be combined with other hypothalamic releasing hormones in a single test of anterior pituitary reserve, the responses of anterior pituitary hormones to combinations of an i.v. bolus of GHRH(1-29)NH2 or saline with an i.v. bolus of either LH releasing hormone (LHRH) plus TRH, ovine CRH(oCRH) or saline were studied. Each infusion of GHRH(1-29)NH2 resulted in a rapid increment of the plasma GH value. Infusion of GHRH(1-29)NH2 also caused a small and transient rise in plasma PRL, but no change in the integrated PRL response. The combination of GHRH(1-29)NH2 with LHRH plus TRH caused a larger increment of peak and integrated plasma TSH levels than LHRH plus TRH alone. GHRH(1-29)NH2 did not affect the release of other anterior pituitary hormones after infusion with oCRH or LHRH plus TRH. Because of the finding of potentiation of the TSH-releasing activity of LHRH plus TRH by GHRH(1-29)NH2, the study was extended to the investigation of TSH release after infusion of TRH in combination with either GHRH(1-29)NH2 or GHRH(1-40). In this study the combination of TRH with both GHRH preparations also caused a larger increment of the peak and integrated plasma TSH levels than TRH alone. It is concluded that GHRH(1-29)NH2 possesses moderate PRL-releasing activity apart from GH-releasing activity. In addition, GHRH potentiates the TSH-releasing activity of TRH.(ABSTRACT TRUNCATED AT 250 WORDS) |
| spellingShingle | Looij, B Nieuwenhuijzen Kruseman, A Mudde, A Frölich, M Piaditis, G Hodgkinson, S McLean, C Grossman, A Coy, D Rees, L The interaction of growth hormone releasing hormone with other hypothalamic hormones on the release of anterior pituitary hormones. |
| title | The interaction of growth hormone releasing hormone with other hypothalamic hormones on the release of anterior pituitary hormones. |
| title_full | The interaction of growth hormone releasing hormone with other hypothalamic hormones on the release of anterior pituitary hormones. |
| title_fullStr | The interaction of growth hormone releasing hormone with other hypothalamic hormones on the release of anterior pituitary hormones. |
| title_full_unstemmed | The interaction of growth hormone releasing hormone with other hypothalamic hormones on the release of anterior pituitary hormones. |
| title_short | The interaction of growth hormone releasing hormone with other hypothalamic hormones on the release of anterior pituitary hormones. |
| title_sort | interaction of growth hormone releasing hormone with other hypothalamic hormones on the release of anterior pituitary hormones |
| work_keys_str_mv | AT looijb theinteractionofgrowthhormonereleasinghormonewithotherhypothalamichormonesonthereleaseofanteriorpituitaryhormones AT nieuwenhuijzenkrusemana theinteractionofgrowthhormonereleasinghormonewithotherhypothalamichormonesonthereleaseofanteriorpituitaryhormones AT muddea theinteractionofgrowthhormonereleasinghormonewithotherhypothalamichormonesonthereleaseofanteriorpituitaryhormones AT frolichm theinteractionofgrowthhormonereleasinghormonewithotherhypothalamichormonesonthereleaseofanteriorpituitaryhormones AT piaditisg theinteractionofgrowthhormonereleasinghormonewithotherhypothalamichormonesonthereleaseofanteriorpituitaryhormones AT hodgkinsons theinteractionofgrowthhormonereleasinghormonewithotherhypothalamichormonesonthereleaseofanteriorpituitaryhormones AT mcleanc theinteractionofgrowthhormonereleasinghormonewithotherhypothalamichormonesonthereleaseofanteriorpituitaryhormones AT grossmana theinteractionofgrowthhormonereleasinghormonewithotherhypothalamichormonesonthereleaseofanteriorpituitaryhormones AT coyd theinteractionofgrowthhormonereleasinghormonewithotherhypothalamichormonesonthereleaseofanteriorpituitaryhormones AT reesl theinteractionofgrowthhormonereleasinghormonewithotherhypothalamichormonesonthereleaseofanteriorpituitaryhormones AT looijb interactionofgrowthhormonereleasinghormonewithotherhypothalamichormonesonthereleaseofanteriorpituitaryhormones AT nieuwenhuijzenkrusemana interactionofgrowthhormonereleasinghormonewithotherhypothalamichormonesonthereleaseofanteriorpituitaryhormones AT muddea interactionofgrowthhormonereleasinghormonewithotherhypothalamichormonesonthereleaseofanteriorpituitaryhormones AT frolichm interactionofgrowthhormonereleasinghormonewithotherhypothalamichormonesonthereleaseofanteriorpituitaryhormones AT piaditisg interactionofgrowthhormonereleasinghormonewithotherhypothalamichormonesonthereleaseofanteriorpituitaryhormones AT hodgkinsons interactionofgrowthhormonereleasinghormonewithotherhypothalamichormonesonthereleaseofanteriorpituitaryhormones AT mcleanc interactionofgrowthhormonereleasinghormonewithotherhypothalamichormonesonthereleaseofanteriorpituitaryhormones AT grossmana interactionofgrowthhormonereleasinghormonewithotherhypothalamichormonesonthereleaseofanteriorpituitaryhormones AT coyd interactionofgrowthhormonereleasinghormonewithotherhypothalamichormonesonthereleaseofanteriorpituitaryhormones AT reesl interactionofgrowthhormonereleasinghormonewithotherhypothalamichormonesonthereleaseofanteriorpituitaryhormones |