Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells
Around the time of gastrulation in higher vertebrate embryos, inductive interactions direct cells to form central nervous system (neural plate) or sensory placodes. Grafts of different tissues into the periphery of a chicken embryo elicit different responses: Hensen's node induces a neural plat...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
National Academy of Sciences
2018
|
| _version_ | 1826274252263784448 |
|---|---|
| author | Trevers, K Prajapati, R Hintze, M Stower, M Strobl, A Tambalo, M Ranganathan, R Moncaut, N Khan, M Stern, C Streit, A |
| author_facet | Trevers, K Prajapati, R Hintze, M Stower, M Strobl, A Tambalo, M Ranganathan, R Moncaut, N Khan, M Stern, C Streit, A |
| author_sort | Trevers, K |
| collection | OXFORD |
| description | Around the time of gastrulation in higher vertebrate embryos, inductive interactions direct cells to form central nervous system (neural plate) or sensory placodes. Grafts of different tissues into the periphery of a chicken embryo elicit different responses: Hensen's node induces a neural plate whereas the head mesoderm induces placodes. How different are these processes? Transcriptome analysis in time course reveals that both processes start by induction of a common set of genes, which later diverge. These genes are remarkably similar to those induced by an extraembryonic tissue, the hypoblast, and are normally expressed in the pregastrulation stage epiblast. Explants of this epiblast grown in the absence of further signals develop as neural plate border derivatives and eventually express lens markers. We designate this state as "preborder"; its transcriptome resembles embryonic stem cells. Finally, using sequential transplantation experiments, we show that the node, head mesoderm, and hypoblast are interchangeable to begin any of these inductions while the final outcome depends on the tissue emitting the later signals. |
| first_indexed | 2024-03-06T22:40:38Z |
| format | Journal article |
| id | oxford-uuid:5b6b0dea-e638-47bb-9349-fb35e96669f4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:40:38Z |
| publishDate | 2018 |
| publisher | National Academy of Sciences |
| record_format | dspace |
| spelling | oxford-uuid:5b6b0dea-e638-47bb-9349-fb35e96669f42022-03-26T17:21:58ZNeural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cellsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5b6b0dea-e638-47bb-9349-fb35e96669f4EnglishSymplectic Elements at OxfordNational Academy of Sciences2018Trevers, KPrajapati, RHintze, MStower, MStrobl, ATambalo, MRanganathan, RMoncaut, NKhan, MStern, CStreit, AAround the time of gastrulation in higher vertebrate embryos, inductive interactions direct cells to form central nervous system (neural plate) or sensory placodes. Grafts of different tissues into the periphery of a chicken embryo elicit different responses: Hensen's node induces a neural plate whereas the head mesoderm induces placodes. How different are these processes? Transcriptome analysis in time course reveals that both processes start by induction of a common set of genes, which later diverge. These genes are remarkably similar to those induced by an extraembryonic tissue, the hypoblast, and are normally expressed in the pregastrulation stage epiblast. Explants of this epiblast grown in the absence of further signals develop as neural plate border derivatives and eventually express lens markers. We designate this state as "preborder"; its transcriptome resembles embryonic stem cells. Finally, using sequential transplantation experiments, we show that the node, head mesoderm, and hypoblast are interchangeable to begin any of these inductions while the final outcome depends on the tissue emitting the later signals. |
| spellingShingle | Trevers, K Prajapati, R Hintze, M Stower, M Strobl, A Tambalo, M Ranganathan, R Moncaut, N Khan, M Stern, C Streit, A Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells |
| title | Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells |
| title_full | Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells |
| title_fullStr | Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells |
| title_full_unstemmed | Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells |
| title_short | Neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and ES cells |
| title_sort | neural induction by the node and placode induction by head mesoderm share an initial state resembling neural plate border and es cells |
| work_keys_str_mv | AT treversk neuralinductionbythenodeandplacodeinductionbyheadmesodermshareaninitialstateresemblingneuralplateborderandescells AT prajapatir neuralinductionbythenodeandplacodeinductionbyheadmesodermshareaninitialstateresemblingneuralplateborderandescells AT hintzem neuralinductionbythenodeandplacodeinductionbyheadmesodermshareaninitialstateresemblingneuralplateborderandescells AT stowerm neuralinductionbythenodeandplacodeinductionbyheadmesodermshareaninitialstateresemblingneuralplateborderandescells AT strobla neuralinductionbythenodeandplacodeinductionbyheadmesodermshareaninitialstateresemblingneuralplateborderandescells AT tambalom neuralinductionbythenodeandplacodeinductionbyheadmesodermshareaninitialstateresemblingneuralplateborderandescells AT ranganathanr neuralinductionbythenodeandplacodeinductionbyheadmesodermshareaninitialstateresemblingneuralplateborderandescells AT moncautn neuralinductionbythenodeandplacodeinductionbyheadmesodermshareaninitialstateresemblingneuralplateborderandescells AT khanm neuralinductionbythenodeandplacodeinductionbyheadmesodermshareaninitialstateresemblingneuralplateborderandescells AT sternc neuralinductionbythenodeandplacodeinductionbyheadmesodermshareaninitialstateresemblingneuralplateborderandescells AT streita neuralinductionbythenodeandplacodeinductionbyheadmesodermshareaninitialstateresemblingneuralplateborderandescells |