Strategies in the design and use of synthetic "internal glycan" vaccines
The relative structural conservation of "internal glycans" in the cell walls of pathogens suggests that they might as target epitopes less prone to variation and hence with greater potential universality as vaccine targets. Examples of such glycans include the inner core sugars of lipopoly...
| Main Authors: | , , , |
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| Format: | Book section |
| Language: | English |
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Elsevier
2017
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| _version_ | 1826274254493057024 |
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| author | Lakshminarayanan, A Vijayakrishnan, B Bayley, H Davis, B |
| author_facet | Lakshminarayanan, A Vijayakrishnan, B Bayley, H Davis, B |
| author_sort | Lakshminarayanan, A |
| collection | OXFORD |
| description | The relative structural conservation of "internal glycans" in the cell walls of pathogens suggests that they might as target epitopes less prone to variation and hence with greater potential universality as vaccine targets. Examples of such glycans include the inner core sugars of lipopolysaccharides in Gram-negative bacteria. However, due to the buried nature of such internal epitopes, this approach has been rarely adopted. Here we briefly review and compare strategic approaches and outline practical methods associated with evaluating one synergistic strategy that combines (i) blocking of the display of "external glycans" with (ii) vaccination targeted at "internal glycans." |
| first_indexed | 2024-03-06T22:40:40Z |
| format | Book section |
| id | oxford-uuid:5b6f4aa5-e19a-4360-b011-f28f702f9328 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:40:40Z |
| publishDate | 2017 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:5b6f4aa5-e19a-4360-b011-f28f702f93282022-03-26T17:22:02ZStrategies in the design and use of synthetic "internal glycan" vaccinesBook sectionhttp://purl.org/coar/resource_type/c_3248uuid:5b6f4aa5-e19a-4360-b011-f28f702f9328EnglishSymplectic Elements at OxfordElsevier2017Lakshminarayanan, AVijayakrishnan, BBayley, HDavis, BThe relative structural conservation of "internal glycans" in the cell walls of pathogens suggests that they might as target epitopes less prone to variation and hence with greater potential universality as vaccine targets. Examples of such glycans include the inner core sugars of lipopolysaccharides in Gram-negative bacteria. However, due to the buried nature of such internal epitopes, this approach has been rarely adopted. Here we briefly review and compare strategic approaches and outline practical methods associated with evaluating one synergistic strategy that combines (i) blocking of the display of "external glycans" with (ii) vaccination targeted at "internal glycans." |
| spellingShingle | Lakshminarayanan, A Vijayakrishnan, B Bayley, H Davis, B Strategies in the design and use of synthetic "internal glycan" vaccines |
| title | Strategies in the design and use of synthetic "internal glycan" vaccines |
| title_full | Strategies in the design and use of synthetic "internal glycan" vaccines |
| title_fullStr | Strategies in the design and use of synthetic "internal glycan" vaccines |
| title_full_unstemmed | Strategies in the design and use of synthetic "internal glycan" vaccines |
| title_short | Strategies in the design and use of synthetic "internal glycan" vaccines |
| title_sort | strategies in the design and use of synthetic internal glycan vaccines |
| work_keys_str_mv | AT lakshminarayanana strategiesinthedesignanduseofsyntheticinternalglycanvaccines AT vijayakrishnanb strategiesinthedesignanduseofsyntheticinternalglycanvaccines AT bayleyh strategiesinthedesignanduseofsyntheticinternalglycanvaccines AT davisb strategiesinthedesignanduseofsyntheticinternalglycanvaccines |