The association of Shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect.

The association of Shiga-like toxin with detergent-resistant membranes is modulated by glucosylceramide and is an essential requirement in the endoplasmic reticulum for a cytotoxic effect.

Receptor-mediated internalization to the endoplasmic reticulum (ER) and subsequent retro-translocation to the cytosol are essential sequential processes required for the productive intoxication of susceptible mammalian cells by Shiga-like toxin-1 (SLTx). Recently, it has been proposed that the obser...

Полное описание

Библиографические подробности
Главные авторы:	Smith, D, Sillence, D, Falguières, T, Jarvis, R, Johannes, L, Lord, J, Platt, F, Roberts, L
Формат:	Journal article
Язык:	English
Опубликовано:	2006

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