An integrated approach to defining genetic and environmental determinants for major clinical outcomes involving vitamin D
There is substantial genetic and epidemiological evidence implicating vitamin D in the pathogenesis of many common diseases. A number of studies have sought to define an association for disease with sequence variation in the VDR gene, encoding the ligand-activated nuclear hormone receptor for vitami...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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Springer International Publishing
2014
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| _version_ | 1797070576431398912 |
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| author | Berlanga-Taylor, A Knight, J |
| author_facet | Berlanga-Taylor, A Knight, J |
| author_sort | Berlanga-Taylor, A |
| collection | OXFORD |
| description | There is substantial genetic and epidemiological evidence implicating vitamin D in the pathogenesis of many common diseases. A number of studies have sought to define an association for disease with sequence variation in the VDR gene, encoding the ligand-activated nuclear hormone receptor for vitamin D. The results of such studies have been difficult to replicate and are likely to need to account for specific environmental exposures. Here, we review recent work that has begun to study the interactions between VDR gene polymorphisms, vitamin D blood levels, and complex disease susceptibility, notably in the context of major clinical outcomes. We highlight the challenges moving forward in this area and its importance for effective clinical translation of current research. © 2014 The Author(s). |
| first_indexed | 2024-03-06T22:40:51Z |
| format | Journal article |
| id | oxford-uuid:5b7dad4b-09f7-4ea0-a60e-00aeab5c35e4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:40:51Z |
| publishDate | 2014 |
| publisher | Springer International Publishing |
| record_format | dspace |
| spelling | oxford-uuid:5b7dad4b-09f7-4ea0-a60e-00aeab5c35e42022-03-26T17:22:25ZAn integrated approach to defining genetic and environmental determinants for major clinical outcomes involving vitamin DJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5b7dad4b-09f7-4ea0-a60e-00aeab5c35e4EnglishSymplectic Elements at OxfordSpringer International Publishing2014Berlanga-Taylor, AKnight, JThere is substantial genetic and epidemiological evidence implicating vitamin D in the pathogenesis of many common diseases. A number of studies have sought to define an association for disease with sequence variation in the VDR gene, encoding the ligand-activated nuclear hormone receptor for vitamin D. The results of such studies have been difficult to replicate and are likely to need to account for specific environmental exposures. Here, we review recent work that has begun to study the interactions between VDR gene polymorphisms, vitamin D blood levels, and complex disease susceptibility, notably in the context of major clinical outcomes. We highlight the challenges moving forward in this area and its importance for effective clinical translation of current research. © 2014 The Author(s). |
| spellingShingle | Berlanga-Taylor, A Knight, J An integrated approach to defining genetic and environmental determinants for major clinical outcomes involving vitamin D |
| title | An integrated approach to defining genetic and environmental determinants for major clinical outcomes involving vitamin D |
| title_full | An integrated approach to defining genetic and environmental determinants for major clinical outcomes involving vitamin D |
| title_fullStr | An integrated approach to defining genetic and environmental determinants for major clinical outcomes involving vitamin D |
| title_full_unstemmed | An integrated approach to defining genetic and environmental determinants for major clinical outcomes involving vitamin D |
| title_short | An integrated approach to defining genetic and environmental determinants for major clinical outcomes involving vitamin D |
| title_sort | integrated approach to defining genetic and environmental determinants for major clinical outcomes involving vitamin d |
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