Exposure of the HIV-1 broadly neutralizing antibody 10E8 MPER epitope on the membrane surface by gp41 transmembrane domain scaffolds

Exposure of the HIV-1 broadly neutralizing antibody 10E8 MPER epitope on the membrane surface by gp41 transmembrane domain scaffolds

The 10E8 antibody achieves near-pan neutralization of HIV-1 by targeting the remarkably conserved gp41 membrane-proximal external region (MPER) and the connected transmembrane domain (TMD) of the HIV-1 envelope glycoprotein (Env). Thus, recreating the structure that generates 10E8-like antibodies is...

Full description

Bibliographic Details
Main Authors:	Oakes, V, Torralba, J, Rujas, E, Nieva, J, Domene, C, Apellaniz, B
Format:	Journal article
Language:	English
Published:	Elsevier 2018

Similar Items

Cholesterol-dependent membrane fusion induced by the gp41 membrane-proximal external region-transmembrane domain connection suggests a mechanism for broad HIV-1 neutralization.
by: Apellániz, B, et al.
Published: (2014)

The Gp41 Sequence Connecting Mper and Tm Domains Constitutes a Distinct HIV-1 "Fusion Peptide" Targeted by Neutralizing Antibodies
by: Apellaniz, B, et al.
Published: (2014)

Eliciting broadly neutralizing antibodies against HIV-1 that target gp41 MPER
by: Han D, et al.
Published: (2012-09-01)

DNA vaccines that express the MPER of HIV-1 gp41 elicit different antibodies depending upon their transmembrane and cytoplasmic domains
by: Scott JK, et al.
Published: (2012-09-01)

P04-06. Evolution of an anti-MPER gp41 antibody response that mediates broad HIV-1 cross-neutralization
by: Abdool-Karim S, et al.
Published: (2009-10-01)

Antibody to gp41 MPER alters functional properties of HIV-1 Env without complete neutralization.
by: Arthur S Kim, et al.
Published: (2014-07-01)

Structure and immunogenicity of a peptide vaccine, including the complete HIV-1 gp41 2F5 epitope: implications for antibody recognition mechanism and immunogen design.
by: Serrano, S, et al.
Published: (2014)

Multimeric scaffolds displaying the HIV-1 envelope MPER induce MPER-specific antibodies and cross-neutralizing antibodies when co-immunized with gp160 DNA.
by: Shelly J Krebs, et al.
Published: (2014-01-01)

P19-50. Simulation of an MPER peptide samples epitope conformations of two broadly neutralizing antibodies
by: Schmidler SC, et al.
Published: (2009-10-01)

Deep sequencing reveals an association between HIV-1 subtype C mutations in gp41 MPER epitopes and mother-to-child transmission
by: Yin L, et al.
Published: (2012-09-01)

Correction: Multimeric scaffolds displaying the HIV-1 envelope MPER induce MPER-specific antibodies and cross-neutralizing antibodies when co-immunized with gp160 DNA.
by: PLOS ONE Staff
Published: (2015-01-01)

Adsorption and folding dynamics of MPER of HIV-1 gp41 in the presence of dpc micelle
by: Hartono, Yossa Dwi, et al.
Published: (2013)

A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 determinant for neutralization but not for antigen recognition
by: Weissenhorn W, et al.
Published: (2012-09-01)

Molecular recognition of the native HIV-1 MPER revealed by STED microscopy of single virions
by: Carravilla, P, et al.
Published: (2019)

Detection of Novel Neutralizing Antibody Reactivities Against The Membrane Proximal External Region (MPER) of gp41 in HIV-1 Infected Humans
by: Shaw George M
Published: (2005-12-01)

Myomedin scaffold variants targeted to 10E8 HIV-1 broadly neutralizing antibody mimic gp41 epitope and elicit HIV-1 virus-neutralizing sera in mice
by: Milan Kuchař, et al.
Published: (2021-12-01)

Envelope deglycosylation enhances antigenicity of HIV-1 gp41 epitopes for both broad neutralizing antibodies and their unmutated ancestor antibodies.
by: Ben-Jiang Ma, et al.
Published: (2011-09-01)

Chimeric rhinoviruses displaying MPER epitopes elicit anti-HIV neutralizing responses.
by: Guohua Yi, et al.
Published: (2013-01-01)

Induction of HIV neutralizing antibodies against the MPER of the HIV envelope protein by HA/gp41 chimeric protein-based DNA and VLP vaccines.
by: Ling Ye, et al.
Published: (2011-01-01)

Enhancing exposure of HIV-1 neutralization epitopes through mutations in gp41.
by: Catherine A Blish, et al.
Published: (2008-01-01)

The development of HIV vaccines targeting gp41 membrane-proximal external region (MPER): challenges and prospects
by: Huan Liu, et al.
Published: (2018-04-01)

Structure of HIV-1 gp41 with its membrane anchors targeted by neutralizing antibodies
by: Christophe Caillat, et al.
Published: (2021-04-01)

Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape.
by: Constantinos Kurt Wibmer, et al.
Published: (2017-01-01)

Correction: Chimeric Rhinoviruses Displaying MPER Epitopes Elicit Anti-HIV Neutralizing Responses.
by: Guohua Yi, et al.
Published: (2013-01-01)

Analysis of gp41 epitopes in model viral membranes to study HIV-1 neutralization
by: Reichart T, et al.
Published: (2012-09-01)

Lipid Binding: A Necessary Evil for Broadly Neutralizing Anti-gp41 Antibodies?
by: Scherer, E, et al.
Published: (2008)

HIV-1 envelope gp41 broadly neutralizing antibodies: hurdles for vaccine development.
by: Laurent Verkoczy, et al.
Published: (2014-05-01)

Membrane-Active Sequences within gp41 Membrane Proximal External Region (MPER) Modulate MPER-Containing Peptidyl Fusion Inhibitor Activity and the Biosynthesis of HIV-1 Structural Proteins
by: Zhang, Si Min, et al.
Published: (2015)

Membrane-Active Sequences within gp41 Membrane Proximal External Region (MPER) Modulate MPER-Containing Peptidyl Fusion Inhibitor Activity and the Biosynthesis of HIV-1 Structural Proteins.
by: Si Min Zhang, et al.
Published: (2015-01-01)

Bispecific Anti-HIV Immunoadhesins That Bind Gp120 and Gp41 Have Broad and Potent HIV-Neutralizing Activity
by: Seth H. Pincus, et al.
Published: (2021-07-01)

Super Potent Bispecific Llama VHH Antibodies Neutralize HIV via a Combination of gp41 and gp120 Epitopes
by: Nika M. Strokappe, et al.
Published: (2019-06-01)

Dependence on a variable residue limits the breadth of an HIV MPER neutralizing antibody, despite convergent evolution with broadly neutralizing antibodies.
by: Cathrine Scheepers, et al.
Published: (2022-09-01)

Modulation of Cytokine Production by the Transmembrane Envelope Protein gp41 of HIV-1
by: Behrendt Rayk, et al.
Published: (2005-12-01)

Molecular recognition of a membrane-anchored HIV-1 pan-neutralizing epitope
by: Johana Torralba, et al.
Published: (2022-11-01)

Oligomeric structure and three-dimensional fold of the HIV gp41 membrane-proximal external region and transmembrane domain in phospholipid bilayers
by: Kwon, Byungsu, et al.
Published: (2020)

Neutralizing Antibodies Targeting HIV-1 gp41
by: Christophe Caillat, et al.
Published: (2020-10-01)

Epitope exposure on functional, oligomeric HIV-1 gp41 molecules.
by: Sattentau, Q, et al.
Published: (1995)

Interactions of HIV gp41's membrane-proximal external region and transmembrane domain with phospholipid membranes from 31P NMR
by: Sutherland, Madeleine, et al.
Published: (2022)

HIV-1 gp41 core with exposed membrane-proximal external region inducing broad HIV-1 neutralizing antibodies.
by: Ji Wang, et al.
Published: (2011-03-01)

Neutralizing Antibodies Against a Specific Human Immunodeficiency Virus gp41 Epitope are Associated With Long-term Non-progressor Status
by: Olivier Lucar, et al.
Published: (2017-08-01)