Immune cell activation in melioidosis: increased serum levels of interferon-gamma and soluble interleukin-2 receptors without change in soluble CD8 protein.
To evaluate immune cell activation in patients with melioidosis, serum samples were assayed for interferon-gamma (IFN-gamma), soluble interleukin-2 receptors (sIL-2R), and soluble CD8 protein (sCD8). Forty patients with sepsis (23 fatal cases, 17 survivors) and 13 with localized disease were studied...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1991
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| _version_ | 1826274273113669632 |
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| author | Brown, A Dance, D Suputtamongkol, Y Chaowagul, W Kongchareon, S Webster, H White, N |
| author_facet | Brown, A Dance, D Suputtamongkol, Y Chaowagul, W Kongchareon, S Webster, H White, N |
| author_sort | Brown, A |
| collection | OXFORD |
| description | To evaluate immune cell activation in patients with melioidosis, serum samples were assayed for interferon-gamma (IFN-gamma), soluble interleukin-2 receptors (sIL-2R), and soluble CD8 protein (sCD8). Forty patients with sepsis (23 fatal cases, 17 survivors) and 13 with localized disease were studied during acute illness; 12 additional patients were studied after discharge while on maintenance antimicrobial therapy. Serum concentrations of IFN-gamma and sIL-2R were greatly elevated, but sCD8 concentrations were not. These levels increased with disease severity and were associated with fatal outcomes. Macrophage activation by high concentrations of the cytokine IFN-gamma may contribute to pathophysiology and death in septicemic patients. Both IFN-gamma and sIL-2R seem to be predictive of outcome in patients with severe melioidosis and may prove useful in detection of relapse. |
| first_indexed | 2024-03-06T22:40:56Z |
| format | Journal article |
| id | oxford-uuid:5b870e90-0bf1-41d3-8fe8-cc8b7a182936 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:40:56Z |
| publishDate | 1991 |
| record_format | dspace |
| spelling | oxford-uuid:5b870e90-0bf1-41d3-8fe8-cc8b7a1829362022-03-26T17:22:37ZImmune cell activation in melioidosis: increased serum levels of interferon-gamma and soluble interleukin-2 receptors without change in soluble CD8 protein.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5b870e90-0bf1-41d3-8fe8-cc8b7a182936EnglishSymplectic Elements at Oxford1991Brown, ADance, DSuputtamongkol, YChaowagul, WKongchareon, SWebster, HWhite, NTo evaluate immune cell activation in patients with melioidosis, serum samples were assayed for interferon-gamma (IFN-gamma), soluble interleukin-2 receptors (sIL-2R), and soluble CD8 protein (sCD8). Forty patients with sepsis (23 fatal cases, 17 survivors) and 13 with localized disease were studied during acute illness; 12 additional patients were studied after discharge while on maintenance antimicrobial therapy. Serum concentrations of IFN-gamma and sIL-2R were greatly elevated, but sCD8 concentrations were not. These levels increased with disease severity and were associated with fatal outcomes. Macrophage activation by high concentrations of the cytokine IFN-gamma may contribute to pathophysiology and death in septicemic patients. Both IFN-gamma and sIL-2R seem to be predictive of outcome in patients with severe melioidosis and may prove useful in detection of relapse. |
| spellingShingle | Brown, A Dance, D Suputtamongkol, Y Chaowagul, W Kongchareon, S Webster, H White, N Immune cell activation in melioidosis: increased serum levels of interferon-gamma and soluble interleukin-2 receptors without change in soluble CD8 protein. |
| title | Immune cell activation in melioidosis: increased serum levels of interferon-gamma and soluble interleukin-2 receptors without change in soluble CD8 protein. |
| title_full | Immune cell activation in melioidosis: increased serum levels of interferon-gamma and soluble interleukin-2 receptors without change in soluble CD8 protein. |
| title_fullStr | Immune cell activation in melioidosis: increased serum levels of interferon-gamma and soluble interleukin-2 receptors without change in soluble CD8 protein. |
| title_full_unstemmed | Immune cell activation in melioidosis: increased serum levels of interferon-gamma and soluble interleukin-2 receptors without change in soluble CD8 protein. |
| title_short | Immune cell activation in melioidosis: increased serum levels of interferon-gamma and soluble interleukin-2 receptors without change in soluble CD8 protein. |
| title_sort | immune cell activation in melioidosis increased serum levels of interferon gamma and soluble interleukin 2 receptors without change in soluble cd8 protein |
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