Understanding the impact of Hib conjugate vaccine on transmission, immunity and disease in the United Kingdom.
A rise in invasive Haemophilus influenzae type b (Hib) infections occurred 8 years after vaccine introduction in the United Kingdom. Aspects of Hib vaccine delivery unique to the United Kingdom have been implicated. The authors developed a fully age-structured deterministic susceptible-infected-resi...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2008
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| _version_ | 1797070596050255872 |
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| author | McVernon, J Ramsay, M Mclean, A |
| author_facet | McVernon, J Ramsay, M Mclean, A |
| author_sort | McVernon, J |
| collection | OXFORD |
| description | A rise in invasive Haemophilus influenzae type b (Hib) infections occurred 8 years after vaccine introduction in the United Kingdom. Aspects of Hib vaccine delivery unique to the United Kingdom have been implicated. The authors developed a fully age-structured deterministic susceptible-infected-resistant-susceptible mathematical model, expressed as a set of partial differential equations, to better understand the causes of declining vaccine effectiveness. We also investigated the consequences of the vaccine's impact on reducing Hib transmission for maintenance of immunity. Our findings emphasized the importance of maintaining high post-immunization antibody titres among age groups at greatest risk of invasive infections. In keeping with UK population-based estimates, low direct efficacy of immunological memory against disease was found, cautioning against over-reliance on evidence of priming alone as a correlate of population protection. The contribution of herd immunity to disease control was reinforced. Possible intervention strategies will be explored in subsequent work. |
| first_indexed | 2024-03-06T22:41:09Z |
| format | Journal article |
| id | oxford-uuid:5b99879e-dede-4882-856f-698b45a12b19 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:41:09Z |
| publishDate | 2008 |
| record_format | dspace |
| spelling | oxford-uuid:5b99879e-dede-4882-856f-698b45a12b192022-03-26T17:23:02ZUnderstanding the impact of Hib conjugate vaccine on transmission, immunity and disease in the United Kingdom.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5b99879e-dede-4882-856f-698b45a12b19EnglishSymplectic Elements at Oxford2008McVernon, JRamsay, MMclean, AA rise in invasive Haemophilus influenzae type b (Hib) infections occurred 8 years after vaccine introduction in the United Kingdom. Aspects of Hib vaccine delivery unique to the United Kingdom have been implicated. The authors developed a fully age-structured deterministic susceptible-infected-resistant-susceptible mathematical model, expressed as a set of partial differential equations, to better understand the causes of declining vaccine effectiveness. We also investigated the consequences of the vaccine's impact on reducing Hib transmission for maintenance of immunity. Our findings emphasized the importance of maintaining high post-immunization antibody titres among age groups at greatest risk of invasive infections. In keeping with UK population-based estimates, low direct efficacy of immunological memory against disease was found, cautioning against over-reliance on evidence of priming alone as a correlate of population protection. The contribution of herd immunity to disease control was reinforced. Possible intervention strategies will be explored in subsequent work. |
| spellingShingle | McVernon, J Ramsay, M Mclean, A Understanding the impact of Hib conjugate vaccine on transmission, immunity and disease in the United Kingdom. |
| title | Understanding the impact of Hib conjugate vaccine on transmission, immunity and disease in the United Kingdom. |
| title_full | Understanding the impact of Hib conjugate vaccine on transmission, immunity and disease in the United Kingdom. |
| title_fullStr | Understanding the impact of Hib conjugate vaccine on transmission, immunity and disease in the United Kingdom. |
| title_full_unstemmed | Understanding the impact of Hib conjugate vaccine on transmission, immunity and disease in the United Kingdom. |
| title_short | Understanding the impact of Hib conjugate vaccine on transmission, immunity and disease in the United Kingdom. |
| title_sort | understanding the impact of hib conjugate vaccine on transmission immunity and disease in the united kingdom |
| work_keys_str_mv | AT mcvernonj understandingtheimpactofhibconjugatevaccineontransmissionimmunityanddiseaseintheunitedkingdom AT ramsaym understandingtheimpactofhibconjugatevaccineontransmissionimmunityanddiseaseintheunitedkingdom AT mcleana understandingtheimpactofhibconjugatevaccineontransmissionimmunityanddiseaseintheunitedkingdom |