The effect of BDNF val66met polymorphism on visuomotor adaptation
Brain-derived neurotrophic factor (BDNF) plays an important role in learning, memory, and brain plasticity. Humans with a val66met polymorphism in the BDNF gene have reduced levels of BDNF and alterations in motor learning and short-term cortical plasticity. In the current study, we sought to furthe...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal article |
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2012
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| _version_ | 1797070596249485312 |
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| author | Joundi, R Brittain, J Jenkinson, N Cheeran, B Brown, P Lopez-Alonso, V Lago, A Fernandez-Del-Olmo, M Gomez-Garre, P Mir, P |
| author_facet | Joundi, R Brittain, J Jenkinson, N Cheeran, B Brown, P Lopez-Alonso, V Lago, A Fernandez-Del-Olmo, M Gomez-Garre, P Mir, P |
| author_sort | Joundi, R |
| collection | OXFORD |
| description | Brain-derived neurotrophic factor (BDNF) plays an important role in learning, memory, and brain plasticity. Humans with a val66met polymorphism in the BDNF gene have reduced levels of BDNF and alterations in motor learning and short-term cortical plasticity. In the current study, we sought to further explore the role of BDNF in motor learning by testing human subjects on a visuomotor adaptation task. In experiment 1, 21 subjects with the polymorphism (val/met) and 21 matched controls (val/val) were tested during learning, short-term retention (45 min), long-term retention (24 h), and de-adaptation of a 60° visuomotor deviation. We measured both mean error as well as rate of adaptation during each session. There was no difference in mean error between groups; however, val/met subjects had a reduced rate of adaptation during learning as well as during long-term retention, but not short-term retention or de-adaptation. In experiment 2, 12 val/met and 12 val/val subjects were tested on a larger 80° deviation, revealing a more pronounced difference in mean error during adaptation than the 60° deviation. These results suggest that BDNF may play an important role in visuomotor adaptive processes in the human. © 2012 Springer-Verlag. |
| first_indexed | 2024-03-06T22:41:09Z |
| format | Journal article |
| id | oxford-uuid:5b998eba-15d4-4831-92bb-64ad1ffce9b3 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T22:41:09Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:5b998eba-15d4-4831-92bb-64ad1ffce9b32022-03-26T17:23:03ZThe effect of BDNF val66met polymorphism on visuomotor adaptationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5b998eba-15d4-4831-92bb-64ad1ffce9b3Symplectic Elements at Oxford2012Joundi, RBrittain, JJenkinson, NCheeran, BBrown, PLopez-Alonso, VLago, AFernandez-Del-Olmo, MGomez-Garre, PMir, PBrain-derived neurotrophic factor (BDNF) plays an important role in learning, memory, and brain plasticity. Humans with a val66met polymorphism in the BDNF gene have reduced levels of BDNF and alterations in motor learning and short-term cortical plasticity. In the current study, we sought to further explore the role of BDNF in motor learning by testing human subjects on a visuomotor adaptation task. In experiment 1, 21 subjects with the polymorphism (val/met) and 21 matched controls (val/val) were tested during learning, short-term retention (45 min), long-term retention (24 h), and de-adaptation of a 60° visuomotor deviation. We measured both mean error as well as rate of adaptation during each session. There was no difference in mean error between groups; however, val/met subjects had a reduced rate of adaptation during learning as well as during long-term retention, but not short-term retention or de-adaptation. In experiment 2, 12 val/met and 12 val/val subjects were tested on a larger 80° deviation, revealing a more pronounced difference in mean error during adaptation than the 60° deviation. These results suggest that BDNF may play an important role in visuomotor adaptive processes in the human. © 2012 Springer-Verlag. |
| spellingShingle | Joundi, R Brittain, J Jenkinson, N Cheeran, B Brown, P Lopez-Alonso, V Lago, A Fernandez-Del-Olmo, M Gomez-Garre, P Mir, P The effect of BDNF val66met polymorphism on visuomotor adaptation |
| title | The effect of BDNF val66met polymorphism on visuomotor adaptation |
| title_full | The effect of BDNF val66met polymorphism on visuomotor adaptation |
| title_fullStr | The effect of BDNF val66met polymorphism on visuomotor adaptation |
| title_full_unstemmed | The effect of BDNF val66met polymorphism on visuomotor adaptation |
| title_short | The effect of BDNF val66met polymorphism on visuomotor adaptation |
| title_sort | effect of bdnf val66met polymorphism on visuomotor adaptation |
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