Nonequilibrium chromosome looping via molecular slip links

Nonequilibrium chromosome looping via molecular slip links

We propose a model for the formation of chromatin loops based on the diffusive sliding of molecular slip links. These mimic the behavior of molecules like cohesin, which, along with the CTCF protein, stabilize loops which contribute to organizing the genome. By combining 3D Brownian dynamics simulat...

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Bibliographic Details
Main Authors:	Brackley, C, Johnson, J, Michieletto, D, Morozov, A, Nicodemi, M, Cook, P, Marenduzzo, D
Format:	Journal article
Published:	American Physical Society 2017

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