Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models.

Epistatic and functional interactions of catechol-o-methyltransferase (COMT) and AKT1 on neuregulin1-ErbB signaling in cell models.

BACKGROUND: Neuregulin1 (NRG1)-ErbB signaling has been implicated in the pathogenesis of cancer and schizophrenia. We have previously reported that NRG1-stimulated migration of B lymphoblasts is PI3K-AKT1dependent and impaired in patients with schizophrenia and significantly linked to the catechol-...

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Detalhes bibliográficos
Main Authors:	Sei, Y, Li, Z, Song, J, Ren-Patterson, R, Tunbridge, E, Iizuka, Y, Inoue, M, Alfonso, B, Beltaifa, S, Nakai, Y, Kolachana, B, Chen, J, Weinberger, DR
Formato:	Journal article
Idioma:	English
Publicado em:	Public Library of Science 2010

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