Identification and structure of the nerve growth factor binding site on TrkA.

Identification and structure of the nerve growth factor binding site on TrkA.

Nerve growth factor (NGF) is involved in the development and maintenance of the nervous system and has been implicated as a possible therapeutic target molecule in a number of neurodegenerative diseases, especially Alzheimer's disease. NGF binds with high affinity to the extracellular region of...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Robertson, A, Banfield, M, Allen, S, Dando, J, Mason, G, Tyler, S, Bennett, G, Brain, S, Clarke, A, Naylor, R, Wilcock, G, Brady, R, Dawbarn, D
Định dạng:	Journal article
Ngôn ngữ:	English
Được phát hành:	2001

Những quyển sách tương tự

Immunoglobulin-like domains define the nerve growth factor binding site of the TrkA receptor.
Bằng: Holden, P, et al.
Được phát hành: (1997)

Structure of TrkAIg2 and molecular modelling of the neurotrophin binding sites of the Trk receptors
Bằng: Robertson, A, et al.
Được phát hành: (2000)

A discrete domain of the human TrkB receptor defines the binding sites for BDNF and NT-4.
Bằng: Naylor, R, et al.
Được phát hành: (2002)

Profound and selective loss of catalytic TrkB immunoreactivity in Alzheimer's disease.
Bằng: Allen, S, et al.
Được phát hành: (1999)

Recombinant human nerve growth factor for clinical trials: protein expression, purification, stability and characterisation of binding to infusion pumps.
Bằng: Allen, S, et al.
Được phát hành: (2001)

NGF-TrkA signaling in sensory nerves is required for skeletal adaptation to mechanical loads in mice
Bằng: Tomlinson, R, et al.
Được phát hành: (2017)

NGF-TrkA signaling by sensory nerves coordinates the vascularization and ossification of developing endochondral bone
Bằng: Tomlinson, R, et al.
Được phát hành: (2016)

NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone
Bằng: Tomlinson, R, et al.
Được phát hành: (2016)

Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles
Bằng: Ashley J. Mason, et al.
Được phát hành: (2023-03-01)

Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain.
Bằng: Allen, S, et al.
Được phát hành: (1994)

Expression of Nerve Growth Factor and Its Receptor TrkA in the Reproductive System of Adult Zebrafish
Bằng: Pietro Cacialli
Được phát hành: (2022-05-01)

TrkA regulates the regenerative capacity of bone marrow stromal stem cells in nerve grafts
Bằng: Mei-Ge Zheng, et al.
Được phát hành: (2019-01-01)

NGF-TrkA Signaling by Sensory Nerves Coordinates the Vascularization and Ossification of Developing Endochondral Bone
Bằng: Ryan E. Tomlinson, et al.
Được phát hành: (2016-09-01)

Hypofunctional TrkA Accounts for the Absence of Pain Sensitization in the African Naked Mole-Rat
Bằng: Damir Omerbašić, et al.
Được phát hành: (2016-10-01)

TrkA is a binding partner of NPM‐ALK that promotes the survival of ALK+ T‐cell lymphoma
Bằng: Wenyu Shi, et al.
Được phát hành: (2017-09-01)

NGF causes TrkA to specifically attract microtubules to lipid rafts.
Bằng: Shona Pryor, et al.
Được phát hành: (2012-01-01)

NERVE GROWTH-FACTOR RECEPTOR-BINDING IN NORMAL AND ALZHEIMERS-DISEASE BASAL FOREBRAIN
Bằng: Treanor, J, et al.
Được phát hành: (1990)

The biological effects of endogenous nerve growth factor on adult sensory neurons revealed by a trkA-IgG fusion molecule.
Bằng: McMahon, S, et al.
Được phát hành: (1995)

Low levels of the nerve growth factor receptor TrkA in JIA: a possible defect in a novel anti-inflammatory mechanism
Bằng: Bracci-Laudiero L, et al.
Được phát hành: (2011-09-01)

Low levels of the nerve growth factor receptor TrkA in JIA: a possible defect in a novel anti-inflammatory mechanism
Bằng: Bracci-Laudiero L, et al.
Được phát hành: (2011-09-01)

Syntaxin 1A is a novel binding protein for presenilin-1
Bằng: Allen, S, et al.
Được phát hành: (2000)

Identification of syntaxin 1A as a novel binding protein for presenilin-1.
Bằng: Smith, S, et al.
Được phát hành: (2000)

Engineered Sensory Nerve Guides Self‐Adaptive Bone Healing via NGF‐TrkA Signaling Pathway
Bằng: Zengjie Zhang, et al.
Được phát hành: (2023-04-01)

Dynamic expression of nerve growth factor and its receptor TrkA after subarachnoid hemorrhage in rat brain
Bằng: Jin-ning Song, et al.
Được phát hành: (2016-01-01)

Enhanced TrkA signaling impairs basal forebrain-dependent behavior
Bằng: Laura Calvo-Enrique, et al.
Được phát hành: (2023-09-01)

Postnatal changes in the expression of the trkA high-affinity NGF receptor in primary sensory neurons.
Bằng: Bennett, D, et al.
Được phát hành: (1996)

Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation.
Bằng: Sylvia Josephy-Hernandez, et al.
Được phát hành: (2019-01-01)

Low affinity nerve growth factor receptor binding in normal and Alzheimer's disease basal forebrain.
Bằng: Treanor, J, et al.
Được phát hành: (1991)

Hyperglycemia causes renal cell damage via CCN2-induced activation of the TrkA receptor: implications for diabetic nephropathy.
Bằng: Fragiadaki, M, et al.
Được phát hành: (2012)

Trypanosoma cruzi coaxes cardiac fibroblasts into preventing cardiomyocyte death by activating nerve growth factor receptor TrkA.
Bằng: Daniel Aridgides, et al.
Được phát hành: (2013-01-01)

Mouse natural killer (NK) cells express the nerve growth factor receptor TrkA, which is dynamically regulated.
Bằng: Natacha Ralainirina, et al.
Được phát hành: (2010-01-01)

Multivesicular bodies mediate long-range retrograde NGF-TrkA signaling
Bằng: Mengchen Ye, et al.
Được phát hành: (2018-01-01)

Role of NGF/TrkA signaling milieu in depressogenic induction of rat brain
Bằng: Ritabrata Banerjee, et al.
Được phát hành: (2013-10-01)

TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential
Bằng: Hanzhi Zhang, et al.
Được phát hành: (2020-01-01)

Secreted herpes simplex virus-2 glycoprotein G modifies NGF-TrkA signaling to attract free nerve endings to the site of infection.
Bằng: Jorge Rubén Cabrera, et al.
Được phát hành: (2015-01-01)

Nerve growth factor treatment increases brain-derived neurotrophic factor selectively in TrkA-expressing dorsal root ganglion cells and in their central terminations within the spinal cord.
Bằng: Michael, G, et al.
Được phát hành: (1997)

Photosensitive tyrosine analogues unravel site-dependent phosphorylation in TrkA initiated MAPK/ERK signaling
Bằng: Shu Zhao, et al.
Được phát hành: (2020-11-01)

trkA, CGRP and IB4 expression in retrogradely labelled cutaneous and visceral primary sensory neurones in the rat.
Bằng: Bennett, D, et al.
Được phát hành: (1996)

Endothelial TrkA coordinates vascularization and innervation in thermogenic adipose tissue and can be targeted to control metabolism
Bằng: Alexes C. Daquinag, et al.
Được phát hành: (2022-09-01)

Crystal structure of a two-subunit TrkA octameric gating ring assembly.
Bằng: Marc C Deller, et al.
Được phát hành: (2015-01-01)