Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.

Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.

The biosynthesis of penicillin and cephalosporin antibiotics in microorganisms requires the formation of the bicyclic nucleus of penicillin. Isopenicillin N synthase (IPNS), a non-haem iron-dependent oxidase, catalyses the reaction of a tripeptide, delta-(L-alpha-aminoadipoyl)-L-cysteinyl-D-valine (...

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Bibliographic Details
Main Authors:	Roach, P, Clifton, I, Hensgens, C, Shibata, N, Schofield, C, Hajdu, J, Baldwin, J
Format:	Journal article
Language:	English
Published:	1997

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