Third generation of reoxidant for osmium: extension and novel applications
<p>This thesis describes the development of new osmium-mediated methodologies providing novel applications through the use of a third generation of reoxidant for osmium.</p><p>Chapter 1 The introduction</p><p><ul><li>Summary of past and present methodologies...
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| Format: | Thesis |
| Language: | English |
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2011
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| _version_ | 1797070651120418816 |
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| author | Callens, C |
| author2 | Donohoe, T |
| author_facet | Donohoe, T Callens, C |
| author_sort | Callens, C |
| collection | OXFORD |
| description | <p>This thesis describes the development of new osmium-mediated methodologies providing novel applications through the use of a third generation of reoxidant for osmium.</p><p>Chapter 1 The introduction</p><p><ul><li>Summary of past and present methodologies towards the synthesis of the 1,2 amino alcohol motif.</li></ul></p><p>Chapter 2 Intramolecular processes</p><p><ul><li>The studies of the tethered aminohydroxylation (TA) of amide and urea derivatives are being investigated.</li></ul></p><p>Chapter 3 Investigations towards an intermolecular process</p><p><ul><li>The transposition of the TA methodology to an intermolecular process and the requirements involved are discussed. The role of acetamide is being investigated.</li></ul></p><p> Chapter 4 Successful transition to an intermolecular process</p><p><ul><li>Amino acid derivatives became for the first time possible nitrogen sources and were efficiently employed through osmium-mediated reaction to afford interesting biological scaffolds.</li></ul></p><p>Chapter 5 Experimental</p><p><ul><li>Full experimental procedures and characterisation of compounds are reported.</li></ul></p><p>References</p><p><ul><li> A complete list of citations employed in the previous five chapters is provided.</li></ul></p><p> Appendix</p><p><ul><li>Full documentation of X-ray crystal structures, key NMR spectra and HPLC traces is provided.</li></ul></p> |
| first_indexed | 2024-03-06T22:41:58Z |
| format | Thesis |
| id | oxford-uuid:5be1ee62-70b1-4643-9707-87de0487278a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:41:58Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:5be1ee62-70b1-4643-9707-87de0487278a2022-03-26T17:24:42ZThird generation of reoxidant for osmium: extension and novel applicationsThesishttp://purl.org/coar/resource_type/c_db06uuid:5be1ee62-70b1-4643-9707-87de0487278aOrganic chemistryOrganic synthesisEnglishOxford University Research Archive - Valet2011Callens, CDonohoe, T<p>This thesis describes the development of new osmium-mediated methodologies providing novel applications through the use of a third generation of reoxidant for osmium.</p><p>Chapter 1 The introduction</p><p><ul><li>Summary of past and present methodologies towards the synthesis of the 1,2 amino alcohol motif.</li></ul></p><p>Chapter 2 Intramolecular processes</p><p><ul><li>The studies of the tethered aminohydroxylation (TA) of amide and urea derivatives are being investigated.</li></ul></p><p>Chapter 3 Investigations towards an intermolecular process</p><p><ul><li>The transposition of the TA methodology to an intermolecular process and the requirements involved are discussed. The role of acetamide is being investigated.</li></ul></p><p> Chapter 4 Successful transition to an intermolecular process</p><p><ul><li>Amino acid derivatives became for the first time possible nitrogen sources and were efficiently employed through osmium-mediated reaction to afford interesting biological scaffolds.</li></ul></p><p>Chapter 5 Experimental</p><p><ul><li>Full experimental procedures and characterisation of compounds are reported.</li></ul></p><p>References</p><p><ul><li> A complete list of citations employed in the previous five chapters is provided.</li></ul></p><p> Appendix</p><p><ul><li>Full documentation of X-ray crystal structures, key NMR spectra and HPLC traces is provided.</li></ul></p> |
| spellingShingle | Organic chemistry Organic synthesis Callens, C Third generation of reoxidant for osmium: extension and novel applications |
| title | Third generation of reoxidant for osmium: extension and novel applications |
| title_full | Third generation of reoxidant for osmium: extension and novel applications |
| title_fullStr | Third generation of reoxidant for osmium: extension and novel applications |
| title_full_unstemmed | Third generation of reoxidant for osmium: extension and novel applications |
| title_short | Third generation of reoxidant for osmium: extension and novel applications |
| title_sort | third generation of reoxidant for osmium extension and novel applications |
| topic | Organic chemistry Organic synthesis |
| work_keys_str_mv | AT callensc thirdgenerationofreoxidantforosmiumextensionandnovelapplications |