Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.

Reporter ligand NMR screening method for 2-oxoglutarate oxygenase inhibitors.

The human 2-oxoglutarate (2OG) dependent oxygenases belong to a family of structurally related enzymes that play important roles in many biological processes. We report that competition-based NMR methods, using 2OG as a reporter ligand, can be used for quantitative and site-specific screening of lig...

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Bibliographic Details
Main Authors:	Leung, I, Demetriades, M, Hardy, A, Lejeune, C, Smart, T, Szöllössi, A, Kawamura, A, Schofield, C, Claridge, T
Format:	Journal article
Language:	English
Published:	2013

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