Reduced vascular NO bioavailability in diabetes increases platelet activation in vivo.

Reduced vascular NO bioavailability in diabetes increases platelet activation in vivo.

OBJECTIVE: Platelet activation is a feature of cardiovascular disease that is also characterized by endothelial dysfunction. The direct relationship between impaired endothelium-derived NO bioavailability and platelet activation remains unclear. We investigated whether acute inhibition of NO produc...

Full description

Bibliographic Details
Main Authors:	Schäfer, A, Alp, N, Cai, S, Lygate, C, Neubauer, S, Eigenthaler, M, Bauersachs, J, Channon, K
Format:	Journal article
Language:	English
Published:	2004

Similar Items

Reduced vascular nitric oxide bioavailability in diabetes increases platelet activation in vivo: Rescue by endothelium-specific restoration of vascular NO production
by: Schafer, A, et al.
Published: (2003)

Reduced nitric oxide bioactivity increases platelet activation in mice with streptozotocin-induced diabetes mellitus
by: Schafer, A, et al.
Published: (2003)

Rapid regulation of platelet activation in vivo by nitric oxide.
by: Schäfer, A, et al.
Published: (2004)

Rapid regulation of platelet activation and degranulation in vivo by nitric oxide
by: Schafer, A, et al.
Published: (2003)

Rapid regulation of platelet activation in vivo by nitric oxide
by: Schafer, A, et al.
Published: (2003)

Nitric oxide Bioavailability is preserved in diabetes by increased endothelial tetrahydrobiopterin synthesis in targeted GTP cyclohydrolase transgenic mice
by: Alp, N, et al.
Published: (2003)

Diabetes reduces vascular tetrahydrobiopterin levels by oxidation: Insights from a GTPCH-transgenic mouse model
by: Alp, N, et al.
Published: (2003)

The nitric oxide donor pentaerythritol tetranitrate reduces platelet activation in congestive heart failure.
by: Ulrike Flierl, et al.
Published: (2015-01-01)

Increased endothelial tetrahydrobiopterin levels by GTPCH over expression in transgenic mice prevents diabetic endothelial dysfunction
by: Alp, N, et al.
Published: (2003)

PPARgamma activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with Type 2 diabetes.
by: Bagi, Z, et al.
Published: (2004)

Intravenous infusion of 5-methyl-tetrahydrofolate rapidly improves eNOS Coupling. In human vessels by increasing tetrahydrobiopterin bioavailability
by: Antoniades, C, et al.
Published: (2006)

Reduced levels of tetrahydrobiopterin in diabetic mouse model: Effects on endothelial function and nitric oxide (NO) synthase dimerisation
by: Cai, S, et al.
Published: (2004)

Platelet Activity Increases in Patients with Diabetic Retinopathy
by: Gülşah Şiranlı, et al.
Published: (2022-05-01)

Increased endothelial tetrahydrobiopterin reduces in stent stenosis in apolipoprotein E-knockout mice
by: Ali, Z, et al.
Published: (2007)

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
by: Alp, N, et al.
Published: (2004)

Serum adiponectin regulates vascular O2-generation and NO bioavailability in patients with coronary atherosclerosis
by: Antoniades, C, et al.
Published: (2010)

Increased Endothelial Tetrahydrobiopterin Reduces In Stent Stenosis in Apolipoprotein E-Knockout Mice
by: Ali, Z, et al.
Published: (2011)

Enhanced oral bioavailability, reduced irritation and increased hypolipidemic activity of self-assembled capsaicin prodrug nanoparticles
by: Yingshu Feng, et al.
Published: (2018-05-01)

Vaspin increases nitric oxide bioavailability through the reduction of asymmetric dimethylarginine in vascular endothelial cells.
by: Chang Hee Jung, et al.
Published: (2012-01-01)

Akt pathway activation reduces platelet apoptosis and contributes to the increase of platelet counts in solid tumor patients
by: Huan Tian, et al.
Published: (2022-10-01)

Increased endothelial tetrahydrobiopterin levels in GTPCH-transgenic mice
by: Alp, N, et al.
Published: (2002)

Flavored and Nicotine-Containing E-Cigarettes Induce Impaired Angiogenesis and Diabetic Wound Healing via Increased Endothelial Oxidative Stress and Reduced NO Bioavailability
by: Zhuoying Liu, et al.
Published: (2022-05-01)

Associations Between Serum Adiponectin, Vascular O2-Generation and NO Bioavailability In Patients With Coronary Atherosclerosis
by: Antoniades, C, et al.
Published: (2010)

5-Methyl-tetrahydrofolate acid improves endothelial function and decreases superoxide production by improving eNOS coupling and increasing tetrahydrobiopterin bioavailability in human vessels in vivo
by: Antoniades, C, et al.
Published: (2006)

Assessment of the bioavailability of minerals and antioxidant activity of the grain bread in the in vivo experiment
by: Nadezhda N. Alekhina, et al.
Published: (2018-11-01)

Irbesartan lowers superoxide levels and increases nitric oxide bioavailability in blood vessels from spontaneously hypertensive stroke-prone rats.
by: Brosnan, M, et al.
Published: (2002)

Increased endothelial tetrahydrobiopterin synthesis reduces vein graft atherosclerosis in ApoE-knockout mice
by: Ali, Z, et al.
Published: (2005)

Deficiency in endothelial cell tetrahydrobiopterin increases resistance vascular remodelling, blood pressure, and susceptibility to aortic abdominal aneurysm in response to angiotensin II
by: Chuaiphichai, S, et al.
Published: (2018)

Insights into cardiac and vascular remodelling in athletes by multi-modal magnetic resonance imaging
by: Petersen, S, et al.
Published: (2006)

Polymorphism of MTHFR gene affects vascular redox and nitric oxide bioavailability by modifying eNOS coupling
by: Antoniades, C, et al.
Published: (2008)

Editorial: Increasing production of crops with bioavailable micronutrients: a solution to reduce global malnutrition
by: Faisal Nadeem, et al.
Published: (2023-12-01)

An Increase in Mean Platelet Volume/Platelet Count Ratio Is Associated with Vascular Access Failure in Hemodialysis Patients.
by: Dong Ho Shin, et al.
Published: (2017-01-01)

Vascular superoxide generation by NAD(P)H oxidase is increased in humans with type II diabetes mellitus
by: Guzik, T, et al.
Published: (2001)

5-methyl-tetrahydrofolic acid increases nitric oxide bioavailability and decreases superoxide production by improving eNOS coupling in human vessels in vivo: Effects on intracellular tetrahydrobiopterin oxidation
by: Antoniades, C, et al.
Published: (2006)

T2-mapping of ischaemia/reperfusion-injury in the in vivo mouse heart
by: Bohl, S, et al.
Published: (2010)

Creatine reduces mitochondrial permeability transition pore opening in response to oxidative stress in vitro
by: Zervou, S, et al.
Published: (2010)

Plasma asymmetrical-dimethyl-arginine (ADMA) as a regulator of vascular redox and nitric oxide bioavailability in human vessels
by: Antoniades, C, et al.
Published: (2007)

Plasma asymmetrical-dimethyl-arginine (ADMA) regulates nitric oxide bioavailability and vascular superoxide production in human vessels
by: Antoniades, C, et al.
Published: (2007)

Increasing the Bioavailability of Phosphate by Using Microorganisms
by: A. A. A. U. Aberathna, et al.
Published: (2022-01-01)

5-methyl-tetrahydrofolate increases nitric oxide bioavailability and decreases superoxide production by improving eNOS coupling and preventing the intracellular oxidation of tetrahy-drobiopterin, in human vessels in vivo
by: Antoniades, C, et al.
Published: (2006)