Immunodrugs: therapeutic VLP-based vaccines for chronic diseases.
Worldwide, the prevalence of noncommunicable chronic diseases is increasing. The use of vaccines to induce autoantibodies that neutralize disease-related proteins offers a means to effectively and affordably treat such diseases. Twenty vaccines designed to induce therapeutic autoantibodies were clin...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
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2009
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| _version_ | 1797070700461162496 |
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| author | Jennings, G Bachmann, M |
| author_facet | Jennings, G Bachmann, M |
| author_sort | Jennings, G |
| collection | OXFORD |
| description | Worldwide, the prevalence of noncommunicable chronic diseases is increasing. The use of vaccines to induce autoantibodies that neutralize disease-related proteins offers a means to effectively and affordably treat such diseases. Twenty vaccines designed to induce therapeutic autoantibodies were clinically tested in the past 12 years. Immunodrugs are therapeutic vaccines comprising virus-like particles (VLPs) covalently conjugated with self-antigens that induce neutralizing autoantibody responses. Four such VLP-based vaccines have been clinically tested and one has achieved proof of principle: a reduction of blood pressure in hypertensive patients. To facilitate preliminary clinical testing, novel nonclinical study programs have been developed. Safety study designs have considered the underlying B and T cell immunology and have examined potential toxicities of vaccine components and primary and secondary pharmacodynamic action of the vaccines. |
| first_indexed | 2024-03-06T22:42:42Z |
| format | Journal article |
| id | oxford-uuid:5c22f0f4-4eb0-48a9-8fd1-4312f981d473 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:42:42Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:5c22f0f4-4eb0-48a9-8fd1-4312f981d4732022-03-26T17:26:17ZImmunodrugs: therapeutic VLP-based vaccines for chronic diseases.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5c22f0f4-4eb0-48a9-8fd1-4312f981d473EnglishSymplectic Elements at Oxford2009Jennings, GBachmann, MWorldwide, the prevalence of noncommunicable chronic diseases is increasing. The use of vaccines to induce autoantibodies that neutralize disease-related proteins offers a means to effectively and affordably treat such diseases. Twenty vaccines designed to induce therapeutic autoantibodies were clinically tested in the past 12 years. Immunodrugs are therapeutic vaccines comprising virus-like particles (VLPs) covalently conjugated with self-antigens that induce neutralizing autoantibody responses. Four such VLP-based vaccines have been clinically tested and one has achieved proof of principle: a reduction of blood pressure in hypertensive patients. To facilitate preliminary clinical testing, novel nonclinical study programs have been developed. Safety study designs have considered the underlying B and T cell immunology and have examined potential toxicities of vaccine components and primary and secondary pharmacodynamic action of the vaccines. |
| spellingShingle | Jennings, G Bachmann, M Immunodrugs: therapeutic VLP-based vaccines for chronic diseases. |
| title | Immunodrugs: therapeutic VLP-based vaccines for chronic diseases. |
| title_full | Immunodrugs: therapeutic VLP-based vaccines for chronic diseases. |
| title_fullStr | Immunodrugs: therapeutic VLP-based vaccines for chronic diseases. |
| title_full_unstemmed | Immunodrugs: therapeutic VLP-based vaccines for chronic diseases. |
| title_short | Immunodrugs: therapeutic VLP-based vaccines for chronic diseases. |
| title_sort | immunodrugs therapeutic vlp based vaccines for chronic diseases |
| work_keys_str_mv | AT jenningsg immunodrugstherapeuticvlpbasedvaccinesforchronicdiseases AT bachmannm immunodrugstherapeuticvlpbasedvaccinesforchronicdiseases |