Morphogen gradient from a noisy source.
We investigate the effect of time-dependent noise on the shape of a morphogen gradient in a developing embryo. Perturbation theory is used to calculate the deviations from deterministic behavior in a simple reaction-diffusion model of robust gradient formation, and the results are confirmed by numer...
| Main Authors: | , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado: |
2005
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| _version_ | 1826274392718442496 |
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| author | England, J Cardy, J |
| author_facet | England, J Cardy, J |
| author_sort | England, J |
| collection | OXFORD |
| description | We investigate the effect of time-dependent noise on the shape of a morphogen gradient in a developing embryo. Perturbation theory is used to calculate the deviations from deterministic behavior in a simple reaction-diffusion model of robust gradient formation, and the results are confirmed by numerical simulation. It is shown that such deviations can disrupt robustness for sufficiently high noise levels, and the implications of these findings for more complex models of gradient-shaping pathways are discussed. |
| first_indexed | 2024-03-06T22:42:45Z |
| format | Journal article |
| id | oxford-uuid:5c26b626-659f-424b-be90-b190b9bfd679 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:42:45Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:5c26b626-659f-424b-be90-b190b9bfd6792022-03-26T17:26:22ZMorphogen gradient from a noisy source.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5c26b626-659f-424b-be90-b190b9bfd679EnglishSymplectic Elements at Oxford2005England, JCardy, JWe investigate the effect of time-dependent noise on the shape of a morphogen gradient in a developing embryo. Perturbation theory is used to calculate the deviations from deterministic behavior in a simple reaction-diffusion model of robust gradient formation, and the results are confirmed by numerical simulation. It is shown that such deviations can disrupt robustness for sufficiently high noise levels, and the implications of these findings for more complex models of gradient-shaping pathways are discussed. |
| spellingShingle | England, J Cardy, J Morphogen gradient from a noisy source. |
| title | Morphogen gradient from a noisy source. |
| title_full | Morphogen gradient from a noisy source. |
| title_fullStr | Morphogen gradient from a noisy source. |
| title_full_unstemmed | Morphogen gradient from a noisy source. |
| title_short | Morphogen gradient from a noisy source. |
| title_sort | morphogen gradient from a noisy source |
| work_keys_str_mv | AT englandj morphogengradientfromanoisysource AT cardyj morphogengradientfromanoisysource |