Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27.

Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27.

OBJECTIVE: HLA-B27 and endoplasmic reticulum aminopeptidase 1 (ERAP1) are the two strongest genetic factors predisposing to ankylosing spondylitis (AS). A key aminopeptidase in class I major histocompatibility complex presentation, ERAP1 potentially contributes to the pathogenesis of AS by altering...

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Những tác giả chính: Chen, L, Fischer, R, Peng, Y, Reeves, E, McHugh, K, Ternette, N, Hanke, T, Dong, T, Elliott, T, Shastri, N, Kollnberger, S, James, E, Kessler, B, Bowness, P
Định dạng: Journal article
Ngôn ngữ:English
Được phát hành: 2014

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