Genetic architecture of artemisinin-resistant Plasmodium falciparum

We report a large multicenter genome-wide association study of Plasmodium falciparum resistance to artemisinin, the frontline antimalarial drug. Across 15 locations in Southeast Asia, we identified at least 20 mutations in kelch13 (PF3D7_1343700) affecting the encoded propeller and BTB/POZ domains,...

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Detalhes bibliográficos
Principais autores:	Miotto, O, Amato, R, Ashley, EA, MacInnis, B, Almagro-Garcia, J, Amaratunga, C, Lim, P, Mead, D, Oyola, SO, Dhorda, M, Imwong, M, Woodrow, C, Manske, M, Stalker, J, Drury, E, Campino, S, Amenga-Etego, L, Thanh, T-NN, Tran, HT, Ringwald, P, Bethell, D, Nosten, F, Phyo, A, Pukrittayakamee, S, Chotivanich, K, Chuor, CM, Nguon, C, Suon, S, Sreng, S, Newton, PN, Mayxay, M, Khanthavong, M, Hongvanthong, B, Htut, Y, Han, KT, Kyaw, MP, Faiz, MA, Fanello, CI, Onyamboko, M, Mokuolu, OA, Jacob, CG, Takala-Harrison, S, Plowe, CV, Day, NJ, Dondorp, AM, Spencer, CCA, McVean, G, Fairhurst, RM, White, NJ, Kwiatkowski, DP
Formato:	Journal article
Idioma:	English
Publicado em:	Nature Publishing Group 2015

Genetic architecture of artemisinin-resistant Plasmodium falciparum

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