Smoking, alcohol and diet in relation to risk of pancreatic cancer in China: a prospective study of 0.5 million people

In China the incidence of pancreatic cancer (PC) has increased in recent decades. However, little is known about the relevance to PC risk of lifestyle and behavioural factors such as smoking, alcohol drinking, and diet. The China Kadoorie Biobank prospective study recruited 512,891 adults (210,222 m...

Ամբողջական նկարագրություն

Մատենագիտական մանրամասներ
Հիմնական հեղինակներ: Pang, Y, Holmes, M, Guo, Y, Yang, L, Bian, Z, Chen, Y, Iona, A, Millwood, I, Bragg, F, Chen, J, Li, L, Kartsonaki, C, Chen, Z
Ձևաչափ: Journal article
Հրապարակվել է: Wiley 2017
_version_ 1826274430407409664
author Pang, Y
Holmes, M
Guo, Y
Yang, L
Bian, Z
Chen, Y
Iona, A
Millwood, I
Bragg, F
Chen, J
Li, L
Kartsonaki, C
Chen, Z
author_facet Pang, Y
Holmes, M
Guo, Y
Yang, L
Bian, Z
Chen, Y
Iona, A
Millwood, I
Bragg, F
Chen, J
Li, L
Kartsonaki, C
Chen, Z
author_sort Pang, Y
collection OXFORD
description In China the incidence of pancreatic cancer (PC) has increased in recent decades. However, little is known about the relevance to PC risk of lifestyle and behavioural factors such as smoking, alcohol drinking, and diet. The China Kadoorie Biobank prospective study recruited 512,891 adults (210,222 men, 302,669 women) aged 30-79 (mean 52) years from 10 diverse areas during 2004-08. During ~8 years of follow-up, 688 incident cases of PC were recorded among those who had no prior history of cancer at baseline. Cox regression yielded adjusted hazard ratios (HR) for PC associated with smoking, alcohol and selected dietary factors. Overall, 74% of men were ever-regular smokers and 33% of men drank at least weekly, compared with only 3% and 2% of women, respectively. Among men, current regular smoking was associated with an adjusted HR of 1.25 (95% CI 1.08-1.44) for PC, with greater excess risk in urban than rural areas (1.46 [1.19-1.79] vs 1.04 [0.86-1.26]). Heavy, but not light to moderate, alcohol drinking (i.e. ≥420 g/week) was associated with significant excess risk (1.69 [1.21-2.37]), again more extreme in urban than rural areas (1.93 [1.29-2.87] vs 1.35 [0.74-2.48]). Overall, regular consumption of certain foodstuffs was associated with PC risk, with adjusted daily vs never/rare consumption HRs of 0.66 (0.56-0.79) for fresh fruit and 1.16 (1.01-1.33) for red meat. In China, smoking and heavy alcohol drinking were independent risk factors for PC in men. Lower fresh fruit and higher red meat consumption were also associated with higher risk of PC.
first_indexed 2024-03-06T22:43:18Z
format Journal article
id oxford-uuid:5c51c9cf-d635-47b5-b3c4-e6af6b84a035
institution University of Oxford
last_indexed 2024-03-06T22:43:18Z
publishDate 2017
publisher Wiley
record_format dspace
spelling oxford-uuid:5c51c9cf-d635-47b5-b3c4-e6af6b84a0352022-03-26T17:27:34ZSmoking, alcohol and diet in relation to risk of pancreatic cancer in China: a prospective study of 0.5 million peopleJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5c51c9cf-d635-47b5-b3c4-e6af6b84a035Symplectic Elements at OxfordWiley2017Pang, YHolmes, MGuo, YYang, LBian, ZChen, YIona, AMillwood, IBragg, FChen, JLi, LKartsonaki, CChen, ZIn China the incidence of pancreatic cancer (PC) has increased in recent decades. However, little is known about the relevance to PC risk of lifestyle and behavioural factors such as smoking, alcohol drinking, and diet. The China Kadoorie Biobank prospective study recruited 512,891 adults (210,222 men, 302,669 women) aged 30-79 (mean 52) years from 10 diverse areas during 2004-08. During ~8 years of follow-up, 688 incident cases of PC were recorded among those who had no prior history of cancer at baseline. Cox regression yielded adjusted hazard ratios (HR) for PC associated with smoking, alcohol and selected dietary factors. Overall, 74% of men were ever-regular smokers and 33% of men drank at least weekly, compared with only 3% and 2% of women, respectively. Among men, current regular smoking was associated with an adjusted HR of 1.25 (95% CI 1.08-1.44) for PC, with greater excess risk in urban than rural areas (1.46 [1.19-1.79] vs 1.04 [0.86-1.26]). Heavy, but not light to moderate, alcohol drinking (i.e. ≥420 g/week) was associated with significant excess risk (1.69 [1.21-2.37]), again more extreme in urban than rural areas (1.93 [1.29-2.87] vs 1.35 [0.74-2.48]). Overall, regular consumption of certain foodstuffs was associated with PC risk, with adjusted daily vs never/rare consumption HRs of 0.66 (0.56-0.79) for fresh fruit and 1.16 (1.01-1.33) for red meat. In China, smoking and heavy alcohol drinking were independent risk factors for PC in men. Lower fresh fruit and higher red meat consumption were also associated with higher risk of PC.
spellingShingle Pang, Y
Holmes, M
Guo, Y
Yang, L
Bian, Z
Chen, Y
Iona, A
Millwood, I
Bragg, F
Chen, J
Li, L
Kartsonaki, C
Chen, Z
Smoking, alcohol and diet in relation to risk of pancreatic cancer in China: a prospective study of 0.5 million people
title Smoking, alcohol and diet in relation to risk of pancreatic cancer in China: a prospective study of 0.5 million people
title_full Smoking, alcohol and diet in relation to risk of pancreatic cancer in China: a prospective study of 0.5 million people
title_fullStr Smoking, alcohol and diet in relation to risk of pancreatic cancer in China: a prospective study of 0.5 million people
title_full_unstemmed Smoking, alcohol and diet in relation to risk of pancreatic cancer in China: a prospective study of 0.5 million people
title_short Smoking, alcohol and diet in relation to risk of pancreatic cancer in China: a prospective study of 0.5 million people
title_sort smoking alcohol and diet in relation to risk of pancreatic cancer in china a prospective study of 0 5 million people
work_keys_str_mv AT pangy smokingalcoholanddietinrelationtoriskofpancreaticcancerinchinaaprospectivestudyof05millionpeople
AT holmesm smokingalcoholanddietinrelationtoriskofpancreaticcancerinchinaaprospectivestudyof05millionpeople
AT guoy smokingalcoholanddietinrelationtoriskofpancreaticcancerinchinaaprospectivestudyof05millionpeople
AT yangl smokingalcoholanddietinrelationtoriskofpancreaticcancerinchinaaprospectivestudyof05millionpeople
AT bianz smokingalcoholanddietinrelationtoriskofpancreaticcancerinchinaaprospectivestudyof05millionpeople
AT cheny smokingalcoholanddietinrelationtoriskofpancreaticcancerinchinaaprospectivestudyof05millionpeople
AT ionaa smokingalcoholanddietinrelationtoriskofpancreaticcancerinchinaaprospectivestudyof05millionpeople
AT millwoodi smokingalcoholanddietinrelationtoriskofpancreaticcancerinchinaaprospectivestudyof05millionpeople
AT braggf smokingalcoholanddietinrelationtoriskofpancreaticcancerinchinaaprospectivestudyof05millionpeople
AT chenj smokingalcoholanddietinrelationtoriskofpancreaticcancerinchinaaprospectivestudyof05millionpeople
AT lil smokingalcoholanddietinrelationtoriskofpancreaticcancerinchinaaprospectivestudyof05millionpeople
AT kartsonakic smokingalcoholanddietinrelationtoriskofpancreaticcancerinchinaaprospectivestudyof05millionpeople
AT chenz smokingalcoholanddietinrelationtoriskofpancreaticcancerinchinaaprospectivestudyof05millionpeople