Effect of lofepramine on 5-HT function and sleep.
We studied the effect of the tricyclic antidepressant lofepramine (140-210 mg daily for 16 days) on 5-hydroxytryptamine 1A (5-HT1A) receptor sensitivity in healthy volunteers, using a buspirone neuroendocrine challenge paradigm (30 mg orally). We also studied the effect of lofepramine on platelet 5-...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1993
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| _version_ | 1797070752784056320 |
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| author | Herdman, JR Cowen, P Campling, G Hockney, R Laver, D Sharpley, A |
| author_facet | Herdman, JR Cowen, P Campling, G Hockney, R Laver, D Sharpley, A |
| author_sort | Herdman, JR |
| collection | OXFORD |
| description | We studied the effect of the tricyclic antidepressant lofepramine (140-210 mg daily for 16 days) on 5-hydroxytryptamine 1A (5-HT1A) receptor sensitivity in healthy volunteers, using a buspirone neuroendocrine challenge paradigm (30 mg orally). We also studied the effect of lofepramine on platelet 5-HT content and sleep architecture. Lofepramine treatment did not alter the hypothermic, endocrine or amnesic effects of buspirone but significantly lowered platelet 5-HT content and decreased rapid eye movement sleep. Our findings suggest that at clinically used doses, lofepramine inhibits the uptake of 5-HT and produces changes in sleep architecture characteristic of tricyclic antidepressants. However, lofepramine does not appear to alter the sensitivity of 5-HT1A receptors. |
| first_indexed | 2024-03-06T22:43:26Z |
| format | Journal article |
| id | oxford-uuid:5c5ae2de-beea-4dc8-a2a4-1cbd1843d092 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:43:26Z |
| publishDate | 1993 |
| record_format | dspace |
| spelling | oxford-uuid:5c5ae2de-beea-4dc8-a2a4-1cbd1843d0922022-03-26T17:27:47ZEffect of lofepramine on 5-HT function and sleep.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5c5ae2de-beea-4dc8-a2a4-1cbd1843d092EnglishSymplectic Elements at Oxford1993Herdman, JRCowen, PCampling, GHockney, RLaver, DSharpley, AWe studied the effect of the tricyclic antidepressant lofepramine (140-210 mg daily for 16 days) on 5-hydroxytryptamine 1A (5-HT1A) receptor sensitivity in healthy volunteers, using a buspirone neuroendocrine challenge paradigm (30 mg orally). We also studied the effect of lofepramine on platelet 5-HT content and sleep architecture. Lofepramine treatment did not alter the hypothermic, endocrine or amnesic effects of buspirone but significantly lowered platelet 5-HT content and decreased rapid eye movement sleep. Our findings suggest that at clinically used doses, lofepramine inhibits the uptake of 5-HT and produces changes in sleep architecture characteristic of tricyclic antidepressants. However, lofepramine does not appear to alter the sensitivity of 5-HT1A receptors. |
| spellingShingle | Herdman, JR Cowen, P Campling, G Hockney, R Laver, D Sharpley, A Effect of lofepramine on 5-HT function and sleep. |
| title | Effect of lofepramine on 5-HT function and sleep. |
| title_full | Effect of lofepramine on 5-HT function and sleep. |
| title_fullStr | Effect of lofepramine on 5-HT function and sleep. |
| title_full_unstemmed | Effect of lofepramine on 5-HT function and sleep. |
| title_short | Effect of lofepramine on 5-HT function and sleep. |
| title_sort | effect of lofepramine on 5 ht function and sleep |
| work_keys_str_mv | AT herdmanjr effectoflofepramineon5htfunctionandsleep AT cowenp effectoflofepramineon5htfunctionandsleep AT camplingg effectoflofepramineon5htfunctionandsleep AT hockneyr effectoflofepramineon5htfunctionandsleep AT laverd effectoflofepramineon5htfunctionandsleep AT sharpleya effectoflofepramineon5htfunctionandsleep |