Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?

Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?

Metalloproteinases such as the matrix metalloproteinases (MMPs) and disintegrin-metalloproteinases with thrombospondin motifs (ADAMTSs) have been implicated in the pathological destruction of joint tissues in rheumatoid arthritis and osteoarthritis. These enzymes degrade extracellular matrix macromo...

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Bibliographic Details
Main Authors:	Murphy, G, Nagase, H
Format:	Journal article
Language:	English
Published:	2008

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