Fast association rates suggest a conformational change in the MHC class I molecule H-2Db upon peptide binding.

Fast association rates suggest a conformational change in the MHC class I molecule H-2Db upon peptide binding.

Major histocompatibility complex (MHC) class I molecules bind peptides in the endoplasmic reticulum (ER). For this binding reaction, when performed in vitro, widely differing association rates have been reported. We have expressed empty soluble H-2Db class I molecules in Chinese hamster ovary (CHO)...

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Bibliographic Details
Main Authors:	Springer, S, Doring, K, Skipper, J, Townsend, A, Cerundolo, V
Format:	Journal article
Language:	English
Published:	1998

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