A neural circuit mechanism integrating motivational state with memory expression in Drosophila.
Behavioral expression of food-associated memory in fruit flies is constrained by satiety and promoted by hunger, suggesting an influence of motivational state. Here, we identify a neural mechanism that integrates the internal state of hunger and appetitive memory. We show that stimulation of neurons...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2009
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| _version_ | 1797070777294520320 |
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| author | Krashes, M Dasgupta, S Vreede, A White, B Armstrong, J Waddell, S |
| author_facet | Krashes, M Dasgupta, S Vreede, A White, B Armstrong, J Waddell, S |
| author_sort | Krashes, M |
| collection | OXFORD |
| description | Behavioral expression of food-associated memory in fruit flies is constrained by satiety and promoted by hunger, suggesting an influence of motivational state. Here, we identify a neural mechanism that integrates the internal state of hunger and appetitive memory. We show that stimulation of neurons that express neuropeptide F (dNPF), an ortholog of mammalian NPY, mimics food deprivation and promotes memory performance in satiated flies. Robust appetitive memory performance requires the dNPF receptor in six dopaminergic neurons that innervate a distinct region of the mushroom bodies. Blocking these dopaminergic neurons releases memory performance in satiated flies, whereas stimulation suppresses memory performance in hungry flies. Therefore, dNPF and dopamine provide a motivational switch in the mushroom body that controls the output of appetitive memory. |
| first_indexed | 2024-03-06T22:43:49Z |
| format | Journal article |
| id | oxford-uuid:5c7c1a5a-c3eb-4880-977e-ea56ce085b9e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:43:49Z |
| publishDate | 2009 |
| record_format | dspace |
| spelling | oxford-uuid:5c7c1a5a-c3eb-4880-977e-ea56ce085b9e2022-03-26T17:28:30ZA neural circuit mechanism integrating motivational state with memory expression in Drosophila.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5c7c1a5a-c3eb-4880-977e-ea56ce085b9eEnglishSymplectic Elements at Oxford2009Krashes, MDasgupta, SVreede, AWhite, BArmstrong, JWaddell, SBehavioral expression of food-associated memory in fruit flies is constrained by satiety and promoted by hunger, suggesting an influence of motivational state. Here, we identify a neural mechanism that integrates the internal state of hunger and appetitive memory. We show that stimulation of neurons that express neuropeptide F (dNPF), an ortholog of mammalian NPY, mimics food deprivation and promotes memory performance in satiated flies. Robust appetitive memory performance requires the dNPF receptor in six dopaminergic neurons that innervate a distinct region of the mushroom bodies. Blocking these dopaminergic neurons releases memory performance in satiated flies, whereas stimulation suppresses memory performance in hungry flies. Therefore, dNPF and dopamine provide a motivational switch in the mushroom body that controls the output of appetitive memory. |
| spellingShingle | Krashes, M Dasgupta, S Vreede, A White, B Armstrong, J Waddell, S A neural circuit mechanism integrating motivational state with memory expression in Drosophila. |
| title | A neural circuit mechanism integrating motivational state with memory expression in Drosophila. |
| title_full | A neural circuit mechanism integrating motivational state with memory expression in Drosophila. |
| title_fullStr | A neural circuit mechanism integrating motivational state with memory expression in Drosophila. |
| title_full_unstemmed | A neural circuit mechanism integrating motivational state with memory expression in Drosophila. |
| title_short | A neural circuit mechanism integrating motivational state with memory expression in Drosophila. |
| title_sort | neural circuit mechanism integrating motivational state with memory expression in drosophila |
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