N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models

N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models

Ectopic calcification (EC), which is the pathological deposition of calcium and phosphate in extra-skeletal tissues, may be associated with hypercalcaemic and hyperphosphataemic disorders, or it may occur in the absence of metabolic abnormalities. In addition, EC may be inherited as part of several...

書誌詳細
主要な著者:	Esapa, C, Hannan, F, Babinsky, V, Potter, P, Thomas, G, Croucher, P, Brown, M, Brown, S, Cox, R, Thakker, R
フォーマット:	Journal article
言語:	English
出版事項:	Public Library of Science 2015

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