N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models

N-ethyl-N-Nitrosourea (ENU) induced mutations within the klotho gene lead to ectopic calcification and reduced lifespan in mouse models

Ectopic calcification (EC), which is the pathological deposition of calcium and phosphate in extra-skeletal tissues, may be associated with hypercalcaemic and hyperphosphataemic disorders, or it may occur in the absence of metabolic abnormalities. In addition, EC may be inherited as part of several...

书目详细资料
Main Authors:	Esapa, C, Hannan, F, Babinsky, V, Potter, P, Thomas, G, Croucher, P, Brown, M, Brown, S, Cox, R, Thakker, R
格式:	Journal article
语言:	English
出版:	Public Library of Science 2015

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