Characterisation of the HIV-1 reservoir and the potential for viral eradication

Characterisation of the HIV-1 reservoir and the potential for viral eradication

<p>The HIV-1 reservoir is the major barrier to eradication and cure of HIV-1 infection. The aim of this thesis was to characterise the HIV-1 reservoir in PHI and to investigate two potential reservoir clearance strategies.</p> <p>Sensitive Q-PCR assays that quantify HIV-1 DNA reser...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Williams, J, James Williams
Rannpháirtithe:	Frater, J
Formáid:	Tráchtas
Teanga:	English
Foilsithe / Cruthaithe:	2014
Ábhair:	Infectious diseases HIV/AIDS Viruses Immunology

Míreanna comhchosúla

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Architecture of the HIV-1 glycan shield
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Imaging of HIV-1 spread from T cells and Macrophages to Astrocytes
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The impact of HIV-1 disease and its treatment on mycobacterium tuberculosis-specific immunity
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The design and development of an HIV-1 vaccine to elicit a broadly neutralising antibody response
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Population-specific HLA impact in immune control of HIV in Mexico and non-Mexican HIV infected cohorts
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Characterisation of the immune response to PARV4
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The role of Nef protein in the pathogenesis of HIV infection
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The HIV-1 proviral landscape reveals that Nef contributes to HIV-1 persistence in effector memory CD4+ T cells
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Antibody-dependent cellular cytotoxicity responses and susceptibility influence HIV-1 mother-to-child transmission
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Distinct mucosal and systemic immunological characteristics in transgender women potentially relating to HIV acquisition
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Definition of the early HIV-1 signalosome in dendritic cells
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High frequency, sustained T cell responses to PARV4 suggest viral persistence in vivo
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Anti-HIV antibody development up to 1 year after antiretroviral therapy initiation in acute HIV infection
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Gut-derived bacterial toxins impair memory CD4+ T cell mitochondrial function in HIV-1 infection
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Slow progression of pediatric HIV associates with early CD8+ T cell PD-1 expression and a stem-like phenotype
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Higher circulating intermediate monocytes are associated with cognitive function in women with HIV
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Assessment of HIV-1 integration in tissues and subsets across infection stages
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Combined noncanonical NF-κB agonism and targeted BET bromodomain inhibition reverse HIV latency ex vivo
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Interleukin-10 contributes to reservoir establishment and persistence in SIV-infected macaques treated with antiretroviral therapy
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Structural and biophysical studies of HIV Rev and HBV e-antigen
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IL-15 enhances HIV-1 infection by promoting survival and proliferation of CCR5+CD4+ T cells
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The TLR7/IRF-5 axis sensitizes memory CD4+ T cells to Fas-mediated apoptosis during HIV-1 infection
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A functional and structural study of HLA-B*2705 restricted CTL responses associated with delayed HIV-1 disease progression
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Distinct patterns of natural selection in the reverse transcriptase gene of HIV-1 in the presence and absence of antiretroviral therapy
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The latency-reversing agent HODHBt synergizes with IL-15 to enhance cytotoxic function of HIV-specific T cells
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Reprogramming dysfunctional CD8+ T cells to promote properties associated with natural HIV control
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Novel approaches towards characterising the HIV reservoir: A combined microfluidic and target enrichment approach
de réir: Jones, ML
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