Characterisation of the HIV-1 reservoir and the potential for viral eradication

Characterisation of the HIV-1 reservoir and the potential for viral eradication

<p>The HIV-1 reservoir is the major barrier to eradication and cure of HIV-1 infection. The aim of this thesis was to characterise the HIV-1 reservoir in PHI and to investigate two potential reservoir clearance strategies.</p> <p>Sensitive Q-PCR assays that quantify HIV-1 DNA reser...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors:	Williams, J, James Williams
Andre forfattere:	Frater, J
Format:	Thesis
Sprog:	English
Udgivet:	2014
Fag:	Infectious diseases HIV/AIDS Viruses Immunology

Lignende værker

Natural and therapy-induced immune control of HIV-1
af: Yager, N
Udgivet: (2011)

Identification of immunological targets for HIV-1 vaccine and cure strategies
af: Hancock, G
Udgivet: (2014)

The impact of host and therapy mediated selection on HIV-1 evolution
af: Huang, K
Udgivet: (2010)

Naive infection predicts reservoir diversity and is a formidable hurdle to HIV eradication
af: Marilia R. Pinzone, et al.
Udgivet: (2021-08-01)

HLA-B51 associated HIV-1 viral control
af: Peng, Y
Udgivet: (2013)

HIV-1 transmission between T cells and macrophages: consequences for viral pathogenesis.
af: Baxter, A
Udgivet: (2013)

Characterisation of T cells induced by candidate conserved region HIV-1 vaccines in healthy HIV-1/2 negative volunteers
af: Ahmed, T, et al.
Udgivet: (2014)

Immunodominant CD8+ T cell responses to HIV-1 infection - 'The good and the bad'
af: Culshaw, A
Udgivet: (2011)

A study of the phenotype and function of HLA-C restricted CD8 T cells in HIV-1 infection
af: Corrah, TW
Udgivet: (2011)

Architecture of the HIV-1 glycan shield
af: Pritchard, L
Udgivet: (2014)

Imaging of HIV-1 spread from T cells and Macrophages to Astrocytes
af: Do, T
Udgivet: (2014)

The impact of HIV-1 disease and its treatment on mycobacterium tuberculosis-specific immunity
af: Murray, L
Udgivet: (2014)

The design and development of an HIV-1 vaccine to elicit a broadly neutralising antibody response
af: Wan, L, et al.
Udgivet: (2012)

Population-specific HLA impact in immune control of HIV in Mexico and non-Mexican HIV infected cohorts
af: Juarez Molina, CI
Udgivet: (2014)

T-cell receptor (TCR) usage in HIV-2 infection
af: Moysi, E
Udgivet: (2012)

Characterisation of the immune response to PARV4
af: Simmons, RA
Udgivet: (2011)

The role of Nef protein in the pathogenesis of HIV infection
af: Rajapaksa, U
Udgivet: (2013)

HIV-specific interleukin-10 responses and immune modulation
af: Clutton, G
Udgivet: (2012)

The HIV-1 proviral landscape reveals that Nef contributes to HIV-1 persistence in effector memory CD4+ T cells
af: Gabriel Duette, et al.
Udgivet: (2022-04-01)

T cell responses in Kenyan infants: impact on HIV-1 evolution during infection and an assessment of vaccine-induced memory responses in HIV-exposed uninfected infants
af: Garcia Knight, M
Udgivet: (2014)

Killer immunoglobulin-like receptor polymorphism in a Chinese HIV-1 infection cohort
af: Wang, L
Udgivet: (2014)

Distinct mucosal and systemic immunological characteristics in transgender women potentially relating to HIV acquisition
af: Alexandra Schuetz, et al.
Udgivet: (2023-08-01)

Antibody-dependent cellular cytotoxicity responses and susceptibility influence HIV-1 mother-to-child transmission
af: Allison S. Thomas, et al.
Udgivet: (2022-05-01)

Definition of the early HIV-1 signalosome in dendritic cells
af: Khatamzas, E
Udgivet: (2013)

High frequency, sustained T cell responses to PARV4 suggest viral persistence in vivo
af: Simmons, R, et al.
Udgivet: (2011)

Anti-HIV antibody development up to 1 year after antiretroviral therapy initiation in acute HIV infection
af: Julie L. Mitchell, et al.
Udgivet: (2022-01-01)

Gut-derived bacterial toxins impair memory CD4+ T cell mitochondrial function in HIV-1 infection
af: Brian Ferrari, et al.
Udgivet: (2022-05-01)

Slow progression of pediatric HIV associates with early CD8+ T cell PD-1 expression and a stem-like phenotype
af: Vinicius Vieira, et al.
Udgivet: (2023-02-01)

Higher circulating intermediate monocytes are associated with cognitive function in women with HIV
af: Rebecca T. Veenhuis, et al.
Udgivet: (2021-06-01)

Assessment of HIV-1 integration in tissues and subsets across infection stages
af: Vincent H. Wu, et al.
Udgivet: (2020-12-01)

TCF-1 regulates HIV-specific CD8+ T cell expansion capacity
af: Rachel L. Rutishauser, et al.
Udgivet: (2021-02-01)

Interleukin-10 contributes to reservoir establishment and persistence in SIV-infected macaques treated with antiretroviral therapy
af: Justin Harper, et al.
Udgivet: (2022-04-01)

Combined noncanonical NF-κB agonism and targeted BET bromodomain inhibition reverse HIV latency ex vivo
af: Shane D. Falcinelli, et al.
Udgivet: (2022-04-01)

Structural and biophysical studies of HIV Rev and HBV e-antigen
af: DiMattia, M
Udgivet: (2012)

IL-15 enhances HIV-1 infection by promoting survival and proliferation of CCR5+CD4+ T cells
af: Yuhao Li, et al.
Udgivet: (2023-04-01)

The TLR7/IRF-5 axis sensitizes memory CD4+ T cells to Fas-mediated apoptosis during HIV-1 infection
af: Liseth Carmona-Pérez, et al.
Udgivet: (2023-07-01)

A functional and structural study of HLA-B*2705 restricted CTL responses associated with delayed HIV-1 disease progression
af: Pymm, PG
Udgivet: (2012)

Distinct patterns of natural selection in the reverse transcriptase gene of HIV-1 in the presence and absence of antiretroviral therapy
af: Leal, É, et al.
Udgivet: (2004)

Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells
af: Wouter A. van der Heijden, et al.
Udgivet: (2021-04-01)

The latency-reversing agent HODHBt synergizes with IL-15 to enhance cytotoxic function of HIV-specific T cells
af: Dennis C. Copertino Jr., et al.
Udgivet: (2023-09-01)