De novo formation of several features of a centromere following introduction of a Y alphoid YAC into mammalian cells.
The DNA sequence requirements for mammalian centromere function have been investigated by re-introducing human YAC clones containing either centromeric or non-centromeric sequences into hamster and human cells. All YACs integrated into the host chromosomes. In most cell lines produced by spheroplast...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1994
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