Fate-restricted neural progenitors in the mammalian cerebral cortex.
During development of the mammalian cerebral cortex, radial glial cells (RGCs) generate layer-specific subtypes of excitatory neurons in a defined temporal sequence, in which lower-layer neurons are formed before upper-layer neurons. It has been proposed that neuronal subtype fate is determined by b...
| Main Authors: | , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1826274529690779648 |
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| author | Franco, S Gil-Sanz, C Martinez-Garay, I Espinosa, A Harkins-Perry, SR Ramos, C Müller, U |
| author_facet | Franco, S Gil-Sanz, C Martinez-Garay, I Espinosa, A Harkins-Perry, SR Ramos, C Müller, U |
| author_sort | Franco, S |
| collection | OXFORD |
| description | During development of the mammalian cerebral cortex, radial glial cells (RGCs) generate layer-specific subtypes of excitatory neurons in a defined temporal sequence, in which lower-layer neurons are formed before upper-layer neurons. It has been proposed that neuronal subtype fate is determined by birthdate through progressive restriction of the neurogenic potential of a common RGC progenitor. Here, we demonstrate that the murine cerebral cortex contains RGC sublineages with distinct fate potentials. Using in vivo genetic fate mapping and in vitro clonal analysis, we identified an RGC lineage that is intrinsically specified to generate only upper-layer neurons, independently of niche and birthdate. Because upper cortical layers were expanded during primate evolution, amplification of this RGC pool may have facilitated human brain evolution. |
| first_indexed | 2024-03-06T22:44:49Z |
| format | Journal article |
| id | oxford-uuid:5cce39fc-1e69-4e2a-b62d-30721536e9a0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:44:49Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:5cce39fc-1e69-4e2a-b62d-30721536e9a02022-03-26T17:30:28ZFate-restricted neural progenitors in the mammalian cerebral cortex.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5cce39fc-1e69-4e2a-b62d-30721536e9a0EnglishSymplectic Elements at Oxford2012Franco, SGil-Sanz, CMartinez-Garay, IEspinosa, AHarkins-Perry, SRRamos, CMüller, UDuring development of the mammalian cerebral cortex, radial glial cells (RGCs) generate layer-specific subtypes of excitatory neurons in a defined temporal sequence, in which lower-layer neurons are formed before upper-layer neurons. It has been proposed that neuronal subtype fate is determined by birthdate through progressive restriction of the neurogenic potential of a common RGC progenitor. Here, we demonstrate that the murine cerebral cortex contains RGC sublineages with distinct fate potentials. Using in vivo genetic fate mapping and in vitro clonal analysis, we identified an RGC lineage that is intrinsically specified to generate only upper-layer neurons, independently of niche and birthdate. Because upper cortical layers were expanded during primate evolution, amplification of this RGC pool may have facilitated human brain evolution. |
| spellingShingle | Franco, S Gil-Sanz, C Martinez-Garay, I Espinosa, A Harkins-Perry, SR Ramos, C Müller, U Fate-restricted neural progenitors in the mammalian cerebral cortex. |
| title | Fate-restricted neural progenitors in the mammalian cerebral cortex. |
| title_full | Fate-restricted neural progenitors in the mammalian cerebral cortex. |
| title_fullStr | Fate-restricted neural progenitors in the mammalian cerebral cortex. |
| title_full_unstemmed | Fate-restricted neural progenitors in the mammalian cerebral cortex. |
| title_short | Fate-restricted neural progenitors in the mammalian cerebral cortex. |
| title_sort | fate restricted neural progenitors in the mammalian cerebral cortex |
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