A PHABULOSA/cytokinin feedback loop controls root growth in Arabidopsis.
The hormone cytokinin (CK) controls root length in Arabidopsis thaliana by defining where dividing cells, derived from stem cells of the root meristem, start to differentiate [1-6]. However, the regulatory inputs directing CK to promote differentiation remain poorly understood. Here, we show that th...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
2012
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| _version_ | 1797070883538337792 |
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| author | Dello Ioio, R Galinha, C Fletcher, A Grigg, S Molnar, A Willemsen, V Scheres, B Sabatini, S Baulcombe, D Maini, P Tsiantis, M |
| author_facet | Dello Ioio, R Galinha, C Fletcher, A Grigg, S Molnar, A Willemsen, V Scheres, B Sabatini, S Baulcombe, D Maini, P Tsiantis, M |
| author_sort | Dello Ioio, R |
| collection | OXFORD |
| description | The hormone cytokinin (CK) controls root length in Arabidopsis thaliana by defining where dividing cells, derived from stem cells of the root meristem, start to differentiate [1-6]. However, the regulatory inputs directing CK to promote differentiation remain poorly understood. Here, we show that the HD-ZIPIII transcription factor PHABULOSA (PHB) directly activates the CK biosynthesis gene ISOPENTENYL TRANSFERASE 7 (IPT7), thus promoting cell differentiation and regulating root length. We further demonstrate that CK feeds back to repress both PHB and microRNA165, a negative regulator of PHB. These interactions comprise an incoherent regulatory loop in which CK represses both its activator and a repressor of its activator. We propose that this regulatory circuit determines the balance of cell division and differentiation during root development and may provide robustness against CK fluctuations. |
| first_indexed | 2024-03-06T22:45:25Z |
| format | Journal article |
| id | oxford-uuid:5d00b172-9844-4ddf-a197-1a8e5fa4b5f1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:45:25Z |
| publishDate | 2012 |
| record_format | dspace |
| spelling | oxford-uuid:5d00b172-9844-4ddf-a197-1a8e5fa4b5f12022-03-26T17:31:44ZA PHABULOSA/cytokinin feedback loop controls root growth in Arabidopsis.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5d00b172-9844-4ddf-a197-1a8e5fa4b5f1EnglishSymplectic Elements at Oxford2012Dello Ioio, RGalinha, CFletcher, AGrigg, SMolnar, AWillemsen, VScheres, BSabatini, SBaulcombe, DMaini, PTsiantis, MThe hormone cytokinin (CK) controls root length in Arabidopsis thaliana by defining where dividing cells, derived from stem cells of the root meristem, start to differentiate [1-6]. However, the regulatory inputs directing CK to promote differentiation remain poorly understood. Here, we show that the HD-ZIPIII transcription factor PHABULOSA (PHB) directly activates the CK biosynthesis gene ISOPENTENYL TRANSFERASE 7 (IPT7), thus promoting cell differentiation and regulating root length. We further demonstrate that CK feeds back to repress both PHB and microRNA165, a negative regulator of PHB. These interactions comprise an incoherent regulatory loop in which CK represses both its activator and a repressor of its activator. We propose that this regulatory circuit determines the balance of cell division and differentiation during root development and may provide robustness against CK fluctuations. |
| spellingShingle | Dello Ioio, R Galinha, C Fletcher, A Grigg, S Molnar, A Willemsen, V Scheres, B Sabatini, S Baulcombe, D Maini, P Tsiantis, M A PHABULOSA/cytokinin feedback loop controls root growth in Arabidopsis. |
| title | A PHABULOSA/cytokinin feedback loop controls root growth in Arabidopsis. |
| title_full | A PHABULOSA/cytokinin feedback loop controls root growth in Arabidopsis. |
| title_fullStr | A PHABULOSA/cytokinin feedback loop controls root growth in Arabidopsis. |
| title_full_unstemmed | A PHABULOSA/cytokinin feedback loop controls root growth in Arabidopsis. |
| title_short | A PHABULOSA/cytokinin feedback loop controls root growth in Arabidopsis. |
| title_sort | phabulosa cytokinin feedback loop controls root growth in arabidopsis |
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