Bone marrow adiposity and multiple myeloma
Multiple Myeloma (MM) is an incurable haematological malignancy and is the second most common blood cancer in adults; it is caused by the clonal expansion of abnormal plasma cells within the bone marrow and characterized by osteolytic bone lesions, bone pain, renal disease, and immunodeficiency. MM...
| मुख्य लेखकों: | , |
|---|---|
| स्वरूप: | Journal article |
| भाषा: | English |
| प्रकाशित: |
Elsevier
2018
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| _version_ | 1826274575910961152 |
|---|---|
| author | Morris, E Edwards, C |
| author_facet | Morris, E Edwards, C |
| author_sort | Morris, E |
| collection | OXFORD |
| description | Multiple Myeloma (MM) is an incurable haematological malignancy and is the second most common blood cancer in adults; it is caused by the clonal expansion of abnormal plasma cells within the bone marrow and characterized by osteolytic bone lesions, bone pain, renal disease, and immunodeficiency. MM cells infiltrate the bone marrow where they hijack the microenvironment to sustain growth and survival. The contribution to this process by resident bone cells is well defined. However, the role of bone marrow adipocytes is less clear. As one of the most abundant cell types in the bone marrow these cells are surprisingly understudied. However, in the last few decades they have been recognised as having endocrine function. Adipocytes are metabolically active cells that secrete adipokines, growth factors, and inflammatory mediators, they influence the behaviour and function of neighbouring cells; and have the potential to dysregulate normal bone homeostasis. This review discusses how adipocytes contribute to the metastatic niche in multiple myeloma and cancers that metastasise to the bone and how these new discoveries may contribute to further understanding the mechanisms driving the devastating bone disease associated with MM. |
| first_indexed | 2024-03-06T22:45:32Z |
| format | Journal article |
| id | oxford-uuid:5d0ae54e-ec15-4bca-a5b0-2e842cdb6bc8 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:45:32Z |
| publishDate | 2018 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:5d0ae54e-ec15-4bca-a5b0-2e842cdb6bc82022-03-26T17:31:56ZBone marrow adiposity and multiple myelomaJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5d0ae54e-ec15-4bca-a5b0-2e842cdb6bc8EnglishSymplectic Elements at OxfordElsevier2018Morris, EEdwards, CMultiple Myeloma (MM) is an incurable haematological malignancy and is the second most common blood cancer in adults; it is caused by the clonal expansion of abnormal plasma cells within the bone marrow and characterized by osteolytic bone lesions, bone pain, renal disease, and immunodeficiency. MM cells infiltrate the bone marrow where they hijack the microenvironment to sustain growth and survival. The contribution to this process by resident bone cells is well defined. However, the role of bone marrow adipocytes is less clear. As one of the most abundant cell types in the bone marrow these cells are surprisingly understudied. However, in the last few decades they have been recognised as having endocrine function. Adipocytes are metabolically active cells that secrete adipokines, growth factors, and inflammatory mediators, they influence the behaviour and function of neighbouring cells; and have the potential to dysregulate normal bone homeostasis. This review discusses how adipocytes contribute to the metastatic niche in multiple myeloma and cancers that metastasise to the bone and how these new discoveries may contribute to further understanding the mechanisms driving the devastating bone disease associated with MM. |
| spellingShingle | Morris, E Edwards, C Bone marrow adiposity and multiple myeloma |
| title | Bone marrow adiposity and multiple myeloma |
| title_full | Bone marrow adiposity and multiple myeloma |
| title_fullStr | Bone marrow adiposity and multiple myeloma |
| title_full_unstemmed | Bone marrow adiposity and multiple myeloma |
| title_short | Bone marrow adiposity and multiple myeloma |
| title_sort | bone marrow adiposity and multiple myeloma |
| work_keys_str_mv | AT morrise bonemarrowadiposityandmultiplemyeloma AT edwardsc bonemarrowadiposityandmultiplemyeloma |