Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism.

Interleukin-10 regulates TNF-alpha-converting enzyme (TACE/ADAM-17) involving a TIMP-3 dependent and independent mechanism.

IL-10 is a potent anti-inflammatory molecule, which regulates TNF-alpha at multiple levels. We investigated whether IL-10 also modulated the activity of the TNF-alpha-converting enzyme (TACE). Using an ex vivo fluorogenic assay we observed that LPS rapidly induced TACE activity in monocytes coincidi...

Full description

Bibliographic Details
Main Authors:	Brennan, F, Green, P, Amjadi, P, Robertshaw, H, Alvarez-Iglesias, M, Takata, M
Format:	Journal article
Language:	English
Published:	2008

Similar Items

Timp-3 mediates T cell-B cell collaboration by inhibitinp ADAM17/TACE-mediated shedding of CD154.
by: Blumenkron, F, et al.
Published: (2006)

TNFα cleavage beyond TACE/ADAM17: matrix metalloproteinase 13 is a potential therapeutic target in sepsis and colitis
by: Christoph Becker‐Pauly, et al.
Published: (2013-06-01)

Relaxed specificity of matrix metalloproteinases (MMPS) and TIMP insensitivity of tumor necrosis factor-alpha (TNF-alpha) production suggest the major TNF-alpha converting enzyme is not an MMP.
by: Black, R, et al.
Published: (1996)

ADAM17 Genetic Variants and the Response of TNF-α Inhibitor in Rheumatoid Arthritis Patients
by: Kim HJ, et al.
Published: (2020-03-01)

Reactive oxygen species and p38 mitogen-activated protein kinase mediate tumor necrosis factor α-converting enzyme (TACE/ADAM-17) activation in primary human monocytes.
by: Scott, A, et al.
Published: (2011)

Phosphorylation of iRhom2 Controls Stimulated Proteolytic Shedding by the Metalloprotease ADAM17/TACE
by: Miguel Cavadas, et al.
Published: (2017-10-01)

The Important Role of Phosphatidylserine, ADAM17, TNF-Alpha, and Soluble MER on Efferocytosis Activity in Central Obesity
by: Chandra Agung Purnama, et al.
Published: (2024-01-01)

The unfolded protein response controls induction and activation of ADAM17/TACE by severe hypoxia and ER stress.
by: Rzymski, T, et al.
Published: (2012)

Role of the prefrontal cortical protease TACE/ADAM17 in neurobehavioral responses to chronic stress during adolescence
by: Fransua Sharafeddin, et al.
Published: (2024-05-01)

Investigation of the role of TNF-α converting enzyme (TACE) in the inhibition of cell surface and soluble TNF-α production by acute ethanol exposure.
by: Kristine von Maltzan, et al.
Published: (2012-01-01)

Increased Potency of a Bi-specific TL1A-ADAM17 (TACE) Inhibitor by Cell Surface Targeting
by: Tomer Weizman, et al.
Published: (2017-08-01)

Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1).
by: Garton, K, et al.
Published: (2001)

ADAM10 and ADAM17 regulate EGFR, c-Met and TNF RI signalling in liver regeneration and fibrosis
by: Olga Zbodakova, et al.
Published: (2021-06-01)

Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis.
by: Brennan, F, et al.
Published: (1989)

TACE/ADAM17 substrates associate with ACS (Ep-CAM, HB-EGF) and follow-up MACE (TNFR1 and TNFR2)
by: Melody Chemaly, et al.
Published: (2022-12-01)

Tissue inhibitors of metalloproteinases (TIMPs) modulate platelet ADAM10 activity
by: Christine Shu Mei Lee, et al.
Published: (2023-12-01)

Relevance of Inflammatory Cytokine mRNA Expression of Tumour Necrosis Factor- Alpha (TNF α), Interleukin 17A (IL 17A) and Interleukin 6 (IL 6) in Indian Patients with Psoriasis
by: Saiqa R Shah, et al.
Published: (2022-01-01)

TIMP-3 is a potent inhibitor of aggrecanase 1 (ADAM-TS4) and aggrecanase 2 (ADAM-TS5).
by: Kashiwagi, M, et al.
Published: (2001)

LRP-dependent and -independent internalisation of TIMP-3
by: Scilabra, S, et al.
Published: (2011)

TNF-alpha in rheumatoid arthritis and prospects of anti-TNF therapy.
by: Maini, R, et al.
Published: (1993)

4-Hydroxyisoleucine ameliorates an insulin resistant-like state in 3T3-L1 adipocytes by regulating TACE/TIMP3 expression
by: Gao F, et al.
Published: (2015-10-01)

TNF alpha as a therapeutic target in rheumatoid arthritis.
by: Feldmann, M, et al.
Published: (1994)

Unlike for human monocytes after LPS activation, release of TNF-α by THP-1 cells is produced by a TACE catalytically different from constitutive TACE.
by: Helena Moreira-Tabaka, et al.
Published: (2012-01-01)

TACE versus TACE + entecavir versus TACE + tenofovir in the treatment of HBV associated hepatocellular carcinoma
by: Haohao Lu, et al.
Published: (2023-03-01)

TIMP-3 expression in prostate stromal and tumour cells is regulated by androgen and TNF
by: Adeniji, O, et al.
Published: (2007)

TIMP-3 expression is regulated by androgen and TNF in prostate stromal and cancer cells
by: Adeniji, O, et al.
Published: (2008)

Targeting TNF alpha for the therapy of rheumatoid arthritis.
by: Maini, R, et al.
Published: (1994)

TNF alpha--a pivotal role in rheumatoid arthritis?
by: Brennan, F, et al.
Published: (1992)

TNF-alpha and IL-17 cytokine levels in Brazilian patients with ankylosing spondylitis after anti-TNF therapy
by: Fernanda Formaggi Lara-Armi, et al.
Published: (2023-11-01)

ADAM17-triggered TNF signalling protects the ageing Drosophila retina from lipid droplet-mediated degeneration.
by: Muliyil, S, et al.
Published: (2020)

Incomplete response of inflammatory arthritis to TNF alpha blockade is associated with the Th17 pathway
by: Alzabin, S, et al.
Published: (2012)

The role of TNF alpha and IL-1 in rheumatoid arthritis.
by: Feldmann, M, et al.
Published: (2001)

Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist.
by: Butler, D, et al.
Published: (1995)

TNF alpha is an effective therapeutic target for rheumatoid arthritis.
by: Feldmann, M, et al.
Published: (1995)

Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells
by: Jürgen Fritsch, et al.
Published: (2021-11-01)

HIV Nef- and Notch1-dependent Endocytosis of ADAM17 Induces Vesicular TNF Secretion in Chronic HIV Infection
by: Christian Ostalecki, et al.
Published: (2016-11-01)

Optimal interventional treatment for liver cancer: HAIC, TACE or iTACE?
by: Naijian Ge, et al.
Published: (2023-05-01)

Characterization of the Testis-Specific Angiotensin Converting Enzyme (tACE)-Interactome during Bovine Sperm Capacitation
by: Mina Ojaghi, et al.
Published: (2022-01-01)

TNF-alpha in asthma.
by: Berry, M, et al.
Published: (2007)

Beneficial effects of tumour necrosis factor-alpha (TNF-alpha) blockade in rheumatoid arthritis (RA)
by: Maini, R, et al.
Published: (1995)