Magnetic resonance imaging characteristics in patients with psoriatic arthritis and axial manifestations from the MAXIMISE cohort
<p><strong>Objective:</strong> The current analysis of the MAXIMISE trial was conducted to investigate the presence of post-inflammatory and degenerative spinal changes and inflammatory changes in spinal processes identified in baseline MRIs and their potential for predict...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Oxford University Press
2023
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| _version_ | 1826312445544628224 |
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| author | Baraliakos, X Pournara, E Coates, LC Navarro-Compán, V Blanco, R O’Brien, E Schulz, B Landewe, R |
| author_facet | Baraliakos, X Pournara, E Coates, LC Navarro-Compán, V Blanco, R O’Brien, E Schulz, B Landewe, R |
| author_sort | Baraliakos, X |
| collection | OXFORD |
| description | <p><strong>Objective:</strong> The current analysis of the MAXIMISE trial was conducted to investigate the presence of post-inflammatory and degenerative spinal changes and inflammatory changes in spinal processes identified in baseline MRIs and their potential for predicting differential treatment effects in a cohort of PsA patients with axial manifestations.</p>
<p><strong>Methods:</strong> Baseline spinal MRIs from the MAXIMISE trial were re-read to identify additional inflammatory (spinal process), post-inflammatory, and degenerative changes, and investigate the differential treatment effect of these imaging features using logistic regression modelling.</p>
<p><strong>Results:</strong> In addition to bone marrow oedema assessed at primary analysis, spinal process inflammation and post-inflammatory changes evaluated by FAt Spondyloarthritis Spine Score were documented in 11.1% and 20.2% patients, respectively. At least one type of degenerative change was noted in 64% patients, with Pfirrmann grade ≥3 (51.1%) being the most common. Combining primary and re-read MRI findings, 67.1% of patients presented with inflammatory or post-inflammatory changes while 21.2% had degenerative changes alone. Although not statistically significant, post-inflammatory changes were associated with a trend for better efficacy outcomes in terms of ASAS20, ASAS40 and BASDAI50 responses; a trend for worse outcomes was observed in the presence of degenerative changes.</p>
<p><strong>Conclusion:</strong> The current analysis revealed the occurrence of additional inflammatory and post-inflammatory changes suggestive of axial PsA (axPsA) and a trend for better clinical outcomes for patients treated with secukinumab. These results elucidate the imaging characteristics and improve our current understanding of axPsA thereby supporting the interpretation of future trials.</p>
<p><strong>Trial registration: </strong>ClinicalTrials.gov, NCT02721966.</p> |
| first_indexed | 2024-03-07T07:45:21Z |
| format | Journal article |
| id | oxford-uuid:5d0feb8a-1021-4a67-ae33-545cf139adf4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-04-09T03:54:41Z |
| publishDate | 2023 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:5d0feb8a-1021-4a67-ae33-545cf139adf42024-03-07T09:47:23ZMagnetic resonance imaging characteristics in patients with psoriatic arthritis and axial manifestations from the MAXIMISE cohortJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5d0feb8a-1021-4a67-ae33-545cf139adf4EnglishSymplectic ElementsOxford University Press2023Baraliakos, XPournara, ECoates, LCNavarro-Compán, VBlanco, RO’Brien, ESchulz, BLandewe, R<p><strong>Objective:</strong> The current analysis of the MAXIMISE trial was conducted to investigate the presence of post-inflammatory and degenerative spinal changes and inflammatory changes in spinal processes identified in baseline MRIs and their potential for predicting differential treatment effects in a cohort of PsA patients with axial manifestations.</p> <p><strong>Methods:</strong> Baseline spinal MRIs from the MAXIMISE trial were re-read to identify additional inflammatory (spinal process), post-inflammatory, and degenerative changes, and investigate the differential treatment effect of these imaging features using logistic regression modelling.</p> <p><strong>Results:</strong> In addition to bone marrow oedema assessed at primary analysis, spinal process inflammation and post-inflammatory changes evaluated by FAt Spondyloarthritis Spine Score were documented in 11.1% and 20.2% patients, respectively. At least one type of degenerative change was noted in 64% patients, with Pfirrmann grade ≥3 (51.1%) being the most common. Combining primary and re-read MRI findings, 67.1% of patients presented with inflammatory or post-inflammatory changes while 21.2% had degenerative changes alone. Although not statistically significant, post-inflammatory changes were associated with a trend for better efficacy outcomes in terms of ASAS20, ASAS40 and BASDAI50 responses; a trend for worse outcomes was observed in the presence of degenerative changes.</p> <p><strong>Conclusion:</strong> The current analysis revealed the occurrence of additional inflammatory and post-inflammatory changes suggestive of axial PsA (axPsA) and a trend for better clinical outcomes for patients treated with secukinumab. These results elucidate the imaging characteristics and improve our current understanding of axPsA thereby supporting the interpretation of future trials.</p> <p><strong>Trial registration: </strong>ClinicalTrials.gov, NCT02721966.</p> |
| spellingShingle | Baraliakos, X Pournara, E Coates, LC Navarro-Compán, V Blanco, R O’Brien, E Schulz, B Landewe, R Magnetic resonance imaging characteristics in patients with psoriatic arthritis and axial manifestations from the MAXIMISE cohort |
| title | Magnetic resonance imaging characteristics in patients with psoriatic arthritis and axial manifestations from the MAXIMISE cohort |
| title_full | Magnetic resonance imaging characteristics in patients with psoriatic arthritis and axial manifestations from the MAXIMISE cohort |
| title_fullStr | Magnetic resonance imaging characteristics in patients with psoriatic arthritis and axial manifestations from the MAXIMISE cohort |
| title_full_unstemmed | Magnetic resonance imaging characteristics in patients with psoriatic arthritis and axial manifestations from the MAXIMISE cohort |
| title_short | Magnetic resonance imaging characteristics in patients with psoriatic arthritis and axial manifestations from the MAXIMISE cohort |
| title_sort | magnetic resonance imaging characteristics in patients with psoriatic arthritis and axial manifestations from the maximise cohort |
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