The aetiologies of central nervous system infections in hospitalised Cambodian children
<strong>Background</strong> Central nervous system (CNS) infections are an important cause of childhood morbidity and mortality. The aetiologies of these potentially vaccine-preventable infections have not been well established in Cambodia. <strong>Methods</strong> We did a...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Journal article |
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BioMed Central
2017
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| _version_ | 1826274582677422080 |
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| author | Turner, P Suy, K Tan, L Sar, P Miliya, T Hong, N Hang, V Ny, N Soeng, S Day, N van Doorn, H Turner, C |
| author_facet | Turner, P Suy, K Tan, L Sar, P Miliya, T Hong, N Hang, V Ny, N Soeng, S Day, N van Doorn, H Turner, C |
| author_sort | Turner, P |
| collection | OXFORD |
| description | <strong>Background</strong> Central nervous system (CNS) infections are an important cause of childhood morbidity and mortality. The aetiologies of these potentially vaccine-preventable infections have not been well established in Cambodia. <strong>Methods</strong> We did a one year prospective study of children hospitalised with suspected CNS infection at Angkor Hospital for Children, Siem Reap. Cerebrospinal fluid specimens (CSF) samples underwent culture, multiplex PCR and serological analysis to identify a range of bacterial and viral pathogens. Viral metagenomics was performed on a subset of pathogen negative specimens. <strong>Results</strong> Between 1st October 2014 and 30th September 2015, 284 analysable patients were enrolled. The median patient age was 2.6 years; 62.0% were aged <5 years. CSF white blood cell count was ≥10 cells/μL in 116/272 (42.6%) cases. CNS infection was microbiologically confirmed in 55 children (19.3%). Enteroviruses (21/55), Japanese encephalitis virus (17/55), and Streptococcus pneumoniae (7/55) accounted for 45 (81.8%) of all pathogens identified. Of the pathogens detected, 74.5% (41/55) were viruses and 23.6% (13/55) were bacteria. The majority of patients were treated with ceftriaxone empirically. The case fatality rate was 2.5%. <strong>Conclusions</strong> Enteroviruses, JEV and S. pneumoniae are the most frequently detected causes of CNS infection in hospitalised Cambodian children. |
| first_indexed | 2024-03-06T22:45:38Z |
| format | Journal article |
| id | oxford-uuid:5d146189-5e10-4ee2-b39f-075cac24ed25 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T22:45:38Z |
| publishDate | 2017 |
| publisher | BioMed Central |
| record_format | dspace |
| spelling | oxford-uuid:5d146189-5e10-4ee2-b39f-075cac24ed252022-03-26T17:32:09ZThe aetiologies of central nervous system infections in hospitalised Cambodian childrenJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5d146189-5e10-4ee2-b39f-075cac24ed25Symplectic Elements at OxfordBioMed Central2017Turner, PSuy, KTan, LSar, PMiliya, THong, NHang, VNy, NSoeng, SDay, Nvan Doorn, HTurner, C<strong>Background</strong> Central nervous system (CNS) infections are an important cause of childhood morbidity and mortality. The aetiologies of these potentially vaccine-preventable infections have not been well established in Cambodia. <strong>Methods</strong> We did a one year prospective study of children hospitalised with suspected CNS infection at Angkor Hospital for Children, Siem Reap. Cerebrospinal fluid specimens (CSF) samples underwent culture, multiplex PCR and serological analysis to identify a range of bacterial and viral pathogens. Viral metagenomics was performed on a subset of pathogen negative specimens. <strong>Results</strong> Between 1st October 2014 and 30th September 2015, 284 analysable patients were enrolled. The median patient age was 2.6 years; 62.0% were aged <5 years. CSF white blood cell count was ≥10 cells/μL in 116/272 (42.6%) cases. CNS infection was microbiologically confirmed in 55 children (19.3%). Enteroviruses (21/55), Japanese encephalitis virus (17/55), and Streptococcus pneumoniae (7/55) accounted for 45 (81.8%) of all pathogens identified. Of the pathogens detected, 74.5% (41/55) were viruses and 23.6% (13/55) were bacteria. The majority of patients were treated with ceftriaxone empirically. The case fatality rate was 2.5%. <strong>Conclusions</strong> Enteroviruses, JEV and S. pneumoniae are the most frequently detected causes of CNS infection in hospitalised Cambodian children. |
| spellingShingle | Turner, P Suy, K Tan, L Sar, P Miliya, T Hong, N Hang, V Ny, N Soeng, S Day, N van Doorn, H Turner, C The aetiologies of central nervous system infections in hospitalised Cambodian children |
| title | The aetiologies of central nervous system infections in hospitalised Cambodian children |
| title_full | The aetiologies of central nervous system infections in hospitalised Cambodian children |
| title_fullStr | The aetiologies of central nervous system infections in hospitalised Cambodian children |
| title_full_unstemmed | The aetiologies of central nervous system infections in hospitalised Cambodian children |
| title_short | The aetiologies of central nervous system infections in hospitalised Cambodian children |
| title_sort | aetiologies of central nervous system infections in hospitalised cambodian children |
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