Immune monitoring for advanced cell therapy trials in transplantation: which assays and when?
A number of immune regulatory cellular therapies, including regulatory T cells and mesenchymal stromal cells, have emerged as novel alternative therapies for the control of transplant alloresponses. Clinical studies have demonstrated their feasibility and safety, however developing our understanding...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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Frontiers Media
2021
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| _version_ | 1826274583265673216 |
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| author | Stark, HL Wang, HC Kuburic, J Alzhrani, A Hester, J Issa, F |
| author_facet | Stark, HL Wang, HC Kuburic, J Alzhrani, A Hester, J Issa, F |
| author_sort | Stark, HL |
| collection | OXFORD |
| description | A number of immune regulatory cellular therapies, including regulatory T cells and mesenchymal stromal cells, have emerged as novel alternative therapies for the control of transplant alloresponses. Clinical studies have demonstrated their feasibility and safety, however developing our understanding of the impact of cellular therapeutics <i>in vivo</i> requires advanced immune monitoring strategies. To accurately monitor the immune response, a combination of complementary methods is required to measure the cellular and molecular phenotype as well as the function of cells involved. In this review we focus on the current immune monitoring strategies and discuss which methods may be utilized in the future. |
| first_indexed | 2024-03-06T22:45:39Z |
| format | Journal article |
| id | oxford-uuid:5d1567b3-ce47-4921-abf4-4faf6ee53cb0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:45:39Z |
| publishDate | 2021 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:5d1567b3-ce47-4921-abf4-4faf6ee53cb02022-03-26T17:32:13ZImmune monitoring for advanced cell therapy trials in transplantation: which assays and when? Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5d1567b3-ce47-4921-abf4-4faf6ee53cb0EnglishSymplectic ElementsFrontiers Media2021Stark, HLWang, HCKuburic, JAlzhrani, AHester, JIssa, FA number of immune regulatory cellular therapies, including regulatory T cells and mesenchymal stromal cells, have emerged as novel alternative therapies for the control of transplant alloresponses. Clinical studies have demonstrated their feasibility and safety, however developing our understanding of the impact of cellular therapeutics <i>in vivo</i> requires advanced immune monitoring strategies. To accurately monitor the immune response, a combination of complementary methods is required to measure the cellular and molecular phenotype as well as the function of cells involved. In this review we focus on the current immune monitoring strategies and discuss which methods may be utilized in the future. |
| spellingShingle | Stark, HL Wang, HC Kuburic, J Alzhrani, A Hester, J Issa, F Immune monitoring for advanced cell therapy trials in transplantation: which assays and when? |
| title | Immune monitoring for advanced cell therapy trials in transplantation: which assays and when? |
| title_full | Immune monitoring for advanced cell therapy trials in transplantation: which assays and when? |
| title_fullStr | Immune monitoring for advanced cell therapy trials in transplantation: which assays and when? |
| title_full_unstemmed | Immune monitoring for advanced cell therapy trials in transplantation: which assays and when? |
| title_short | Immune monitoring for advanced cell therapy trials in transplantation: which assays and when? |
| title_sort | immune monitoring for advanced cell therapy trials in transplantation which assays and when |
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