Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG

Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG

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Human embryonic stem cell-derived cardiomyocytes (hESC-CM) have been proposed as a new model for safety pharmacology. So far, a thorough description of their basic electrophysiology and extensive testing, and mechanistic explanations, of their overall pro-arrhythmic ability is lacking. Under standar...

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Bibliographic Details
Main Authors:	Jonsson, M, Vos, M, Mirams, G, Duker, G, Sartipy, P, De Boer, T, Van Veen, T
Format:	Journal article
Language:	English
Published:	2012

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