Application of human stem cell-derived cardiomyocytes in safety pharmacology requires caution beyond hERG

Human embryonic stem cell-derived cardiomyocytes (hESC-CM) have been proposed as a new model for safety pharmacology. So far, a thorough description of their basic electrophysiology and extensive testing, and mechanistic explanations, of their overall pro-arrhythmic ability is lacking. Under standar...

Полное описание

Библиографические подробности
Главные авторы: Jonsson, M, Vos, M, Mirams, G, Duker, G, Sartipy, P, De Boer, T, Van Veen, T
Формат: Journal article
Язык:English
Опубликовано: 2012