The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes

The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes

Post-translational methylation plays a crucial role in regulating and optimizing protein function. Protein histidine methylation, occurring as the two isomers 1- and 3-methylhistidine (1MH and 3MH), was first reported five decades ago, but remains largely unexplored. Here we report that METTL9 is a...

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Hlavní autoři: Davydova, E, Shimazu, T, Schuhmacher, MK, Jakobsson, ME, Willemen, HLDM, Liu, T, Moen, A, Ho, AYY, Małecki, J, Schroer, L, Pinto, R, Suzuki, T, Grønsberg, IA, Sohtome, Y, Akakabe, M, Weirich, S, Kikuchi, M, Olsen, JV, Dohmae, N, Umehara, T, Sodeoka, M, Siino, V, McDonough, MA, Eijkelkamp, N, Schofield, CJ, Jeltsch, A, Shinkai, Y, Falnes, PØ
Médium: Journal article
Jazyk:English
Vydáno: Springer Nature 2021

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