A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation

A small-molecule probe for monitoring binding to prolyl hydroxylase domain 2 by fluorescence polarisation

Inhibition of the dioxygen sensing hypoxia-inducible factor prolyl hydroxylases has potential therapeutic benefit for treatment of diseases, including anaemia. We describe the discovery of a small-molecule probe useful for monitoring binding to human prolyl hydroxylase domain 2 (PHD2) via fluorescen...

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Bibliographic Details
Main Authors:	Li, Z, Zhen, S, Anthony, T, Quanwei, Y, Dong, Y, McDonough, M, Schofield, C, Zhang, X
Format:	Journal article
Language:	English
Published:	Royal Society of Chemistry 2020

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