Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice.

Tissue inhibitor of metalloproteinases (TIMP)-1 creates a premetastatic niche in the liver through SDF-1/CXCR4-dependent neutrophil recruitment in mice.

UNLABELLED: Due to its ability to inhibit prometastatic matrix metalloproteinases, tissue inhibitor of metalloproteinases (TIMP)-1 has been thought to suppress tumor metastasis. However, elevated systemic levels of TIMP-1 correlate with poor prognosis in cancer patients, suggesting a metastasis-stim...

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Bibliographic Details
Main Authors: Seubert, B, Grünwald, B, Kobuch, J, Cui, H, Schelter, F, Schaten, S, Siveke, J, Lim, N, Nagase, H, Simonavicius, N, Heikenwalder, M, Reinheckel, T, Sleeman, J, Janssen, K, Knolle, P, Krüger, A
Format: Journal article
Language:English
Published: 2015

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