Linear IgA disease of adults: association with lymphoproliferative malignancy and possible role of other triggering factors.
Seventy patients with linear IgA disease of adults were followed up for a mean of 8.5 years and all malignant diseases in this group were ascertained. There were three cases of lymphoproliferative malignancy, which constituted a significant excess over the 0.2 cases that would be expected by compari...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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1990
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| _version_ | 1797070963389497344 |
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| author | Godfrey, K Wojnarowska, F Leonard, J |
| author_facet | Godfrey, K Wojnarowska, F Leonard, J |
| author_sort | Godfrey, K |
| collection | OXFORD |
| description | Seventy patients with linear IgA disease of adults were followed up for a mean of 8.5 years and all malignant diseases in this group were ascertained. There were three cases of lymphoproliferative malignancy, which constituted a significant excess over the 0.2 cases that would be expected by comparison with an age- and sex-matched population using National Cancer Registry statistics. In contrast, the non-lymphoid malignancy rate of 13% is almost identical to the expected 14%. A subgroup of 35 of the adult linear IgA disease patients were assessed with respect to the possible precipitating illnesses or drugs, as well as co-existing medical conditions. Almost one-third of patients described an event that was felt could possibly have triggered the linear IgA disease, the most frequent being non-steroidal anti-inflammatory or antibiotic drug therapy, trauma/burns and upper respiratory tract infections. However, it is difficult to determine how often the preceding event is coincidental, and how often, if at all, it is causal. |
| first_indexed | 2024-03-06T22:46:26Z |
| format | Journal article |
| id | oxford-uuid:5d56f9e2-731d-4087-a765-6a4f2663258d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T22:46:26Z |
| publishDate | 1990 |
| record_format | dspace |
| spelling | oxford-uuid:5d56f9e2-731d-4087-a765-6a4f2663258d2022-03-26T17:33:55ZLinear IgA disease of adults: association with lymphoproliferative malignancy and possible role of other triggering factors.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5d56f9e2-731d-4087-a765-6a4f2663258dEnglishSymplectic Elements at Oxford1990Godfrey, KWojnarowska, FLeonard, JSeventy patients with linear IgA disease of adults were followed up for a mean of 8.5 years and all malignant diseases in this group were ascertained. There were three cases of lymphoproliferative malignancy, which constituted a significant excess over the 0.2 cases that would be expected by comparison with an age- and sex-matched population using National Cancer Registry statistics. In contrast, the non-lymphoid malignancy rate of 13% is almost identical to the expected 14%. A subgroup of 35 of the adult linear IgA disease patients were assessed with respect to the possible precipitating illnesses or drugs, as well as co-existing medical conditions. Almost one-third of patients described an event that was felt could possibly have triggered the linear IgA disease, the most frequent being non-steroidal anti-inflammatory or antibiotic drug therapy, trauma/burns and upper respiratory tract infections. However, it is difficult to determine how often the preceding event is coincidental, and how often, if at all, it is causal. |
| spellingShingle | Godfrey, K Wojnarowska, F Leonard, J Linear IgA disease of adults: association with lymphoproliferative malignancy and possible role of other triggering factors. |
| title | Linear IgA disease of adults: association with lymphoproliferative malignancy and possible role of other triggering factors. |
| title_full | Linear IgA disease of adults: association with lymphoproliferative malignancy and possible role of other triggering factors. |
| title_fullStr | Linear IgA disease of adults: association with lymphoproliferative malignancy and possible role of other triggering factors. |
| title_full_unstemmed | Linear IgA disease of adults: association with lymphoproliferative malignancy and possible role of other triggering factors. |
| title_short | Linear IgA disease of adults: association with lymphoproliferative malignancy and possible role of other triggering factors. |
| title_sort | linear iga disease of adults association with lymphoproliferative malignancy and possible role of other triggering factors |
| work_keys_str_mv | AT godfreyk linearigadiseaseofadultsassociationwithlymphoproliferativemalignancyandpossibleroleofothertriggeringfactors AT wojnarowskaf linearigadiseaseofadultsassociationwithlymphoproliferativemalignancyandpossibleroleofothertriggeringfactors AT leonardj linearigadiseaseofadultsassociationwithlymphoproliferativemalignancyandpossibleroleofothertriggeringfactors |