Structural aspects of agonism and antagonism in the oestrogen receptor.

Structural aspects of agonism and antagonism in the oestrogen receptor.

We have determined the three-dimensional structures of both alpha- and beta-forms of the ligand-binding domain of the oestrogen receptor (ER) in complexes with a range of receptor agonists and antagonists. Here, we summarize how these structures provide both an understanding of the ER's distinc...

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Autors principals:	Pike, A, Brzozowski, A, Walton, J, Hubbard, R, Bonn, T, Gustafsson, J, Carlquist, M
Format:	Journal article
Idioma:	English
Publicat:	2000

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