Exploratory efficacy of calcium-vitamin D milk fortification and periodontal therapy on maternal oral health and metabolic and inflammatory profile
In this 2 × 2 factorial, outcome-assessor blinded, feasibility randomised trial we explored the effect of a non-pharmaceutical multi-component intervention on periodontal health and metabolic and inflammatory profiles among pregnant women with periodontitis receiving prenatal care in a Brazilian pub...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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MDPI
2021
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| _version_ | 1826311004567371776 |
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| author | Rodrigues Amorim Adegboye, A Dias Santana, D Teixeira Dos Santos, PP Guedes Cocate, P Benaim, C Trindade de Castro, MB Maia Schlussel, M Kac, G Lilienthal Heitmann, B |
| author_facet | Rodrigues Amorim Adegboye, A Dias Santana, D Teixeira Dos Santos, PP Guedes Cocate, P Benaim, C Trindade de Castro, MB Maia Schlussel, M Kac, G Lilienthal Heitmann, B |
| author_sort | Rodrigues Amorim Adegboye, A |
| collection | OXFORD |
| description | In this 2 × 2 factorial, outcome-assessor blinded, feasibility randomised trial we explored the effect of a non-pharmaceutical multi-component intervention on periodontal health and metabolic and inflammatory profiles among pregnant women with periodontitis receiving prenatal care in a Brazilian public health centre. 69 pregnant women (gestational age ≤20 weeks, T0) were randomly allocated into four groups: (1) fortified sachet (vitamin D and calcium) and powdered milk plus periodontal therapy during pregnancy (early PT) (n = 17); (2) placebo sachet and powdered milk plus early PT (n = 15); (3) fortified sachet and powdered milk plus late PT (after delivery) (n = 19); (4) placebo sachet and powdered milk plus late PT (n = 18). Third trimester (T1) and 6-8 weeks postpartum (T2) exploratory outcomes included periodontal health (% sites with bleeding on probing (BOP)), glucose, insulin, C-Reactive Protein, serum calcium and vitamin D. The mean BOP was significantly reduced in the early PT groups, while BOP worsened in the late PT groups. No significant effect of fortification on BOP was observed. Changes in glucose levels and variation on birthweight did not differ among groups This feasibility trial provides preliminary evidence for estimating the minimum clinically important differences for selected maternal outcomes. A large-scale trial to evaluate the interventions' clinical benefits and cost-effectiveness is warranted. |
| first_indexed | 2024-03-07T08:02:01Z |
| format | Journal article |
| id | oxford-uuid:5d9190af-ac7a-4003-9c7a-413d1c6204c1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T08:02:01Z |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | dspace |
| spelling | oxford-uuid:5d9190af-ac7a-4003-9c7a-413d1c6204c12023-10-04T12:25:54ZExploratory efficacy of calcium-vitamin D milk fortification and periodontal therapy on maternal oral health and metabolic and inflammatory profileJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:5d9190af-ac7a-4003-9c7a-413d1c6204c1EnglishSymplectic ElementsMDPI2021Rodrigues Amorim Adegboye, ADias Santana, DTeixeira Dos Santos, PPGuedes Cocate, PBenaim, CTrindade de Castro, MBMaia Schlussel, MKac, GLilienthal Heitmann, BIn this 2 × 2 factorial, outcome-assessor blinded, feasibility randomised trial we explored the effect of a non-pharmaceutical multi-component intervention on periodontal health and metabolic and inflammatory profiles among pregnant women with periodontitis receiving prenatal care in a Brazilian public health centre. 69 pregnant women (gestational age ≤20 weeks, T0) were randomly allocated into four groups: (1) fortified sachet (vitamin D and calcium) and powdered milk plus periodontal therapy during pregnancy (early PT) (n = 17); (2) placebo sachet and powdered milk plus early PT (n = 15); (3) fortified sachet and powdered milk plus late PT (after delivery) (n = 19); (4) placebo sachet and powdered milk plus late PT (n = 18). Third trimester (T1) and 6-8 weeks postpartum (T2) exploratory outcomes included periodontal health (% sites with bleeding on probing (BOP)), glucose, insulin, C-Reactive Protein, serum calcium and vitamin D. The mean BOP was significantly reduced in the early PT groups, while BOP worsened in the late PT groups. No significant effect of fortification on BOP was observed. Changes in glucose levels and variation on birthweight did not differ among groups This feasibility trial provides preliminary evidence for estimating the minimum clinically important differences for selected maternal outcomes. A large-scale trial to evaluate the interventions' clinical benefits and cost-effectiveness is warranted. |
| spellingShingle | Rodrigues Amorim Adegboye, A Dias Santana, D Teixeira Dos Santos, PP Guedes Cocate, P Benaim, C Trindade de Castro, MB Maia Schlussel, M Kac, G Lilienthal Heitmann, B Exploratory efficacy of calcium-vitamin D milk fortification and periodontal therapy on maternal oral health and metabolic and inflammatory profile |
| title | Exploratory efficacy of calcium-vitamin D milk fortification and periodontal therapy on maternal oral health and metabolic and inflammatory profile |
| title_full | Exploratory efficacy of calcium-vitamin D milk fortification and periodontal therapy on maternal oral health and metabolic and inflammatory profile |
| title_fullStr | Exploratory efficacy of calcium-vitamin D milk fortification and periodontal therapy on maternal oral health and metabolic and inflammatory profile |
| title_full_unstemmed | Exploratory efficacy of calcium-vitamin D milk fortification and periodontal therapy on maternal oral health and metabolic and inflammatory profile |
| title_short | Exploratory efficacy of calcium-vitamin D milk fortification and periodontal therapy on maternal oral health and metabolic and inflammatory profile |
| title_sort | exploratory efficacy of calcium vitamin d milk fortification and periodontal therapy on maternal oral health and metabolic and inflammatory profile |
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